@article{3dcf5680bac44ead8fd8f3d668473d17,
title = "Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review)",
abstract = "Lung cancer is the leading cause of cancer‑related mortality worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases. Patients harboring epidermal growth factor receptor (EGFR) mutations usually develop resistance to treatment with frontline EGFR‑tyrosine kinase inhibitors (EGFR‑TKIs). The present review summarizes the current findings and delineates the molecular mechanism of action for the therapeutic effects of herbal extracts and phytochemicals in overcoming EGFR‑TKI resistance in NSCLC. Novel molecular targets underlying EGFR‑TKI resistance in NSCLC are also discussed. This review provides valuable information for the development of herbal bioactive compounds as alternative treatments for EGFR‑TKI‑resistant NSCLC.",
keywords = "non‑small cell lung cancer, epidermal growth factor receptor, herbal medicine, Chinese medicine, drug resistance",
author = "Lee, {Hiu Yan Jennifer} and Mingjing Meng and Yulong Liu and Tao Su and Kwan, {Hiu Yee}",
note = "Funding Information: This study was partially supported by Research Grant Council of HKSAR=Hong Kong Special Administrative Region (grant no. HKBU-22103017-ECS), the Innovation & Technology Commission (grant no. #PRP/015/19FX), the National Natural Science Foundation of China (grant nos. #SCM-2016-NSFC-003, 82074019 and 81703705), the Natural Science Foundation of Guangdong Province (grant no. #2018A0303130122), Characteristic innovation projects of Universities in Guangdong Province (grant no. 2020KTSCX030), and the Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology), Zhejiang Chinese Medical University (grant no. ZYAOX2018010). Publisher copyright: {\textcopyright} Spandidos Publications 2021. All rights reserved.",
year = "2021",
month = sep,
doi = "10.3892/ol.2021.12907",
language = "English",
volume = "22",
journal = "Oncology Letters",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "3",
}
