Lung cancer is the leading cause of cancer‑related mortality worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases. Patients harboring epidermal growth factor receptor (EGFR) mutations usually develop resistance to treatment with frontline EGFR‑tyrosine kinase inhibitors (EGFR‑TKIs). The present review summarizes the current findings and delineates the molecular mechanism of action for the therapeutic effects of herbal extracts and phytochemicals in overcoming EGFR‑TKI resistance in NSCLC. Novel molecular targets underlying EGFR‑TKI resistance in NSCLC are also discussed. This review provides valuable information for the development of herbal bioactive compounds as alternative treatments for EGFR‑TKI‑resistant NSCLC.
- non‑small cell lung cancer
- epidermal growth factor receptor
- herbal medicine
- Chinese medicine
- drug resistance