Medial sigmoid depression of the mandibular ramus as a lesion-mimicking anatomical variation: A systematic review

(1) Background: Medial sigmoid depression (MSD) of the mandibular ramus is an anatomical variation that resembles non-odontogenic cystic lesion. (2) Aim: The aim of this systematic review was to survey the literature to identify the relevant journal publications, reveal their scientific impact in terms of citations and compare the reported prevalence of MSD. (3) Materials and methods: PubMed, Google Scholar, Scopus and Web of Science were queried to identify relevant publications. The search string was: “medial depression of mandibular ramus” OR “medial depression of the mandibular ramus” OR “medial depression of the mandibular rami” OR “medial depression of mandibular rami” OR “medial sigmoid depression”. (4) Results: Eight studies were identified. Dry mandibles and patient dental panoramic radiographs were evaluated in four and seven of the eight studies, respectively. The prevalence of MSD varied from 20.2% to 82.0%. In male and female patients, the prevalence was 18.3–76.0% and 22.0–64.0%, respectively. MSD tended to occur bilaterally and most prevalent in patients with Angle’s Class II occlusion. The semilunar and triangular shapes were more common than teardrop and circular shapes. The most cited study had 12 citations. (5) Conclu-sions: MSD was a seldom investigated and cited anatomical variation that was not uncommon. Its recognition should be further promoted.