TY - JOUR
T1 - Mechanosensitive miRNAs and bone formation
AU - Chen, Zhihao
AU - Zhang, Yan
AU - LIANG, Chao
AU - Chen, Lei
AU - ZHANG, Ge
AU - Qian, Airong
N1 - Funding Information:
This work was supported by funds from the Natural Science Foundation of China (No. 31570940), the Shenzhen Science and Technology Project (JCYJ20160229174320053), the Peak Experience Project of NPU.
PY - 2017/8/2
Y1 - 2017/8/2
N2 - Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli.
AB - Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli.
KW - Bone formation
KW - Mechanical stimuli
KW - Mechanosensitive miRNAs
KW - Osteogenic differentiation
UR - http://www.scopus.com/inward/record.url?scp=85026809168&partnerID=8YFLogxK
U2 - 10.3390/ijms18081684
DO - 10.3390/ijms18081684
M3 - Review article
C2 - 28767056
AN - SCOPUS:85026809168
SN - 1661-6596
VL - 18
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 8
M1 - 1684
ER -