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Mechanistic Studies of Rhodium-Catalyzed Asymmetric Homogeneous Hydrogenation

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Abstract

The reaction pathway for rhodium-catalyzed asymmetric hydrogenation of enamides is described and intermediates are defined in solution by P-31, C-13, and H-1 NMR. The stereochemical relationship of bound enamide to rhodium alkyl and to the product of hydrogenation is demonstrated. Experiments involving the addition of HD to a variety of olefins in the presence of rhodium biphosphine catalysts suggest that a concerted addition of hydrogen to olefin and metal may occur in appropriate cases.
Original languageEnglish
Title of host publicationCatalytic Aspects of Metal Phosphine Complexes
EditorsElmer C. Alyea, Devon W. Meek
PublisherAmerican Chemical Society
Pages355-369
Number of pages15
ISBN (Electronic)9780841223783
ISBN (Print)9780841206014
DOIs
Publication statusPublished - 1 Jun 1982

Publication series

NameAdvances in Chemistry
Volume196
ISSN (Print)0065-2393

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