Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer

Zheng Chen, Shuangying Qiao, Liu Yang, Meiheng Sun, Boyue LI, Aiping Lu*, Fangfei Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

The members of the cytokine interleukin 17 (IL-17) family, along with their receptors (IL-17R), are vital players in a range of inflammatory diseases and cancer. Although generally regarded as proinflammatory, the effects they exhibit on cancer progression are a double-edged sword, with both antitumor and protumor activities being discovered. There is growing evidence that the IL-17 signaling pathways have significant impacts on the tumor microenvironment (TME), immune response, and inflammation in various types of cancer, including pancreatic cancer. However, the detailed mechanistic functions of the IL-17/IL-17R families in pancreatic cancer were rarely systematically elucidated. This review considers the role of the IL-17/IL-17R families in inflammation and tumor immunity and elaborates on the mechanistic functions and correlations of these members with pathogenesis, progression, and chemoresistance in pancreatic cancer. By summarizing the advanced findings on the role of IL-17/IL17R family members and IL-17 signaling pathways at the molecular level, cellular level, and disease level in pancreatic cancer, this review provides an in-depth discussion on the potential of IL-17/IL-17R as prognostic markers and therapeutic targets in pancreatic cancer.
Original languageEnglish
Article number13539
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume24
Issue number17
Early online date31 Aug 2023
DOIs
Publication statusPublished - 1 Sept 2023

Scopus Subject Areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry

User-Defined Keywords

  • IL-17
  • chemotherapy resistance
  • pancreatic cancer
  • tumor immune microenvironment

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