TY - JOUR
T1 - Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants
AU - Duan, Zhihao
AU - Chen, Kai
AU - Yang, Tao
AU - You, Ronghui
AU - Chen, Binzhao
AU - Li, Jianming
AU - Liu, Linchuan
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12/2
Y1 - 2023/12/2
N2 - Maintenance of proteome integrity is essential for cell function and survival in changing cellular and environmental conditions. The endoplasmic reticulum (ER) is the major site for the synthesis of secretory and membrane proteins. However, the accumulation of unfolded or misfolded proteins can perturb ER protein homeostasis, leading to ER stress and compromising cellular function. Eukaryotic organisms have evolved sophisticated and conserved protein quality control systems to ensure protein folding fidelity via the unfolded protein response (UPR) and to eliminate potentially harmful proteins via ER-associated degradation (ERAD) and ER-phagy. In this review, we summarize recent advances in our understanding of the mechanisms of ER protein homeostasis in plants and discuss the crosstalk between different quality control systems. Finally, we will address unanswered questions in this field.
AB - Maintenance of proteome integrity is essential for cell function and survival in changing cellular and environmental conditions. The endoplasmic reticulum (ER) is the major site for the synthesis of secretory and membrane proteins. However, the accumulation of unfolded or misfolded proteins can perturb ER protein homeostasis, leading to ER stress and compromising cellular function. Eukaryotic organisms have evolved sophisticated and conserved protein quality control systems to ensure protein folding fidelity via the unfolded protein response (UPR) and to eliminate potentially harmful proteins via ER-associated degradation (ERAD) and ER-phagy. In this review, we summarize recent advances in our understanding of the mechanisms of ER protein homeostasis in plants and discuss the crosstalk between different quality control systems. Finally, we will address unanswered questions in this field.
KW - ER homeostasis
KW - unfolded protein response (UPR)
KW - ER-associated degradation (ERAD)
KW - ER-phagy
KW - Arabidopsis thaliana
UR - http://www.scopus.com/inward/record.url?scp=85180716737&partnerID=8YFLogxK
U2 - 10.3390/ijms242417599
DO - 10.3390/ijms242417599
M3 - Review article
C2 - 38139432
AN - SCOPUS:85180716737
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 24
M1 - 17599
ER -
