Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

Xinyi Wen; Huishan Li; Zhijie Ju; Renren Deng; David Parker

doi:10.1039/d4sc05743k

Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

Xinyi Wen
, Huishan Li
, Zhijie Ju
, Renren Deng
, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

A series of new ligands has been prepared that incorporate electron-poor aromatic moieties (dpqMe₂ and dpqPh₂ chromophores) into tetraazacyclododecane or triazacyclononane based complex structures, and the time-dependent photophysical properties of their Eu(iii) and Tb(iii) complexes evaluated for the selective and rapid ratiometric analysis of urate in diluted serum solution, together with mechanistic studies probing the nature of the intermediate exciplex and the excited state dynamics using transient absorption spectroscopy.

Original language	English
Pages (from-to)	19944-19951
Number of pages	8
Journal	Chemical Science
Volume	15
Issue number	47
Early online date	7 Nov 2024
DOIs	https://doi.org/10.1039/d4sc05743k
Publication status	Published - 21 Dec 2024

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title = "Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers",

abstract = "A series of new ligands has been prepared that incorporate electron-poor aromatic moieties (dpqMe2 and dpqPh2 chromophores) into tetraazacyclododecane or triazacyclononane based complex structures, and the time-dependent photophysical properties of their Eu(iii) and Tb(iii) complexes evaluated for the selective and rapid ratiometric analysis of urate in diluted serum solution, together with mechanistic studies probing the nature of the intermediate exciplex and the excited state dynamics using transient absorption spectroscopy.",

author = "Xinyi Wen and Huishan Li and Zhijie Ju and Renren Deng and David Parker",

note = "Funding Information: DP thanks the Hong Kong Jockey Club Charities Trust for equipment support and the Hong Kong government and Hong Kong Baptist University for support under the Global STEM Professorship scheme. This work was supported by the National Natural Science Foundation of China (T2122003, 52173290), and the Fundamental Research Funds for the Zhejiang Provincial Universities (226-2024-00131). Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by the Royal Society of Chemistry",

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doi = "10.1039/d4sc05743k",

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T1 - Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

AU - Wen, Xinyi

AU - Li, Huishan

AU - Ju, Zhijie

AU - Deng, Renren

AU - Parker, David

N1 - Funding Information: DP thanks the Hong Kong Jockey Club Charities Trust for equipment support and the Hong Kong government and Hong Kong Baptist University for support under the Global STEM Professorship scheme. This work was supported by the National Natural Science Foundation of China (T2122003, 52173290), and the Fundamental Research Funds for the Zhejiang Provincial Universities (226-2024-00131). Publisher Copyright: © 2024 The Author(s). Published by the Royal Society of Chemistry

PY - 2024/12/21

Y1 - 2024/12/21

N2 - A series of new ligands has been prepared that incorporate electron-poor aromatic moieties (dpqMe2 and dpqPh2 chromophores) into tetraazacyclododecane or triazacyclononane based complex structures, and the time-dependent photophysical properties of their Eu(iii) and Tb(iii) complexes evaluated for the selective and rapid ratiometric analysis of urate in diluted serum solution, together with mechanistic studies probing the nature of the intermediate exciplex and the excited state dynamics using transient absorption spectroscopy.

AB - A series of new ligands has been prepared that incorporate electron-poor aromatic moieties (dpqMe2 and dpqPh2 chromophores) into tetraazacyclododecane or triazacyclononane based complex structures, and the time-dependent photophysical properties of their Eu(iii) and Tb(iii) complexes evaluated for the selective and rapid ratiometric analysis of urate in diluted serum solution, together with mechanistic studies probing the nature of the intermediate exciplex and the excited state dynamics using transient absorption spectroscopy.

UR - https://www.scopus.com/pages/publications/85208804884

U2 - 10.1039/d4sc05743k

DO - 10.1039/d4sc05743k

M3 - Journal article

AN - SCOPUS:85208804884

SN - 2041-6520

VL - 15

SP - 19944

EP - 19951

JO - Chemical Science

JF - Chemical Science

IS - 47

ER -

Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

Abstract

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