TY - JOUR
T1 - Measurement uncertainty for total ash and acid-insoluble ash determination of Chinese materia medica
AU - LEUNG, Kelvin S Y
AU - Chan, Kelvin
AU - Lau, Angus C.K.
AU - Lu, Guanghua
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/7
Y1 - 2005/7
N2 - The total ash and acid-insoluble ash contents of Chinese materia medica (CMM) have been widely used as one of the indices to illustrate the quality as well as purity of herbal medicines. Such an approach has also been adopted by many official organizations in writing monographs for pharmacopoeia worldwide. In the present study, a full validation on the methodology was conducted with the inclusion of various commonly encountered matrices in herbs, namely, leaf, flower, fruit, stem and root. The practice ensures method suitability for a wider scope of matrix variation in CMM. Moreover, in order to comply with the technical requirement of International Organization of Standardization 17025 quality assurance system, the concept of measurement uncertainty has also been incorporated in the present study. Measurement uncertainties for total ash and acid-insoluble ash contents have been estimated.
AB - The total ash and acid-insoluble ash contents of Chinese materia medica (CMM) have been widely used as one of the indices to illustrate the quality as well as purity of herbal medicines. Such an approach has also been adopted by many official organizations in writing monographs for pharmacopoeia worldwide. In the present study, a full validation on the methodology was conducted with the inclusion of various commonly encountered matrices in herbs, namely, leaf, flower, fruit, stem and root. The practice ensures method suitability for a wider scope of matrix variation in CMM. Moreover, in order to comply with the technical requirement of International Organization of Standardization 17025 quality assurance system, the concept of measurement uncertainty has also been incorporated in the present study. Measurement uncertainties for total ash and acid-insoluble ash contents have been estimated.
KW - Ash
KW - Chinese materia medica
KW - Measurement uncertainty
KW - Quantitative analysis
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=21744433512&partnerID=8YFLogxK
U2 - 10.1007/s00769-005-0932-4
DO - 10.1007/s00769-005-0932-4
M3 - Journal article
AN - SCOPUS:21744433512
SN - 0949-1775
VL - 10
SP - 289
EP - 294
JO - Accreditation and Quality Assurance
JF - Accreditation and Quality Assurance
IS - 6
ER -