TY - JOUR
T1 - Matching traditional Chinese medicine and western medicine-based research
T2 - Advanced nutraceutical development for proactive gastric cancer prevention
AU - Micucci, Matteo
AU - Bian, Zhao Xiang
AU - Chen, Min Ting
AU - Kwan, Hiu Yee
AU - Mari, Michele
AU - Retini, Michele
AU - Burattini, Sabrina
AU - Osman, Riham
AU - Okeke, Udodinma Jude
AU - Abdullah, Fuad Othman
AU - Gianfanti, Federico
AU - Battistelli, Michela
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2024/9/15
Y1 - 2024/9/15
N2 - Gastric cancer (GC), the third leading cause of cancer-related death globally, is complex and heterogeneous. This review explores multidisciplinary investigations of traditional Chinese medicine (TCM) combined with Western medical practices, emphasizing the development of nutraceuticals for cancer prevention. Using advanced analytical chemistry and food chemistry techniques, this study investigated how TCM components may be optimized for nutraceutical development. Focusing on molecular interactions with GC pathways, particularly the NF-κB, PI3K/Akt, and Wnt/β-catenin pathways, we examined the effects of TCM polyherbal formulas, extracts, and isolated compounds. These agents modulate apoptosis and cellular proliferation, underscoring their potential in preventive strategies. The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework. This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention. The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.
AB - Gastric cancer (GC), the third leading cause of cancer-related death globally, is complex and heterogeneous. This review explores multidisciplinary investigations of traditional Chinese medicine (TCM) combined with Western medical practices, emphasizing the development of nutraceuticals for cancer prevention. Using advanced analytical chemistry and food chemistry techniques, this study investigated how TCM components may be optimized for nutraceutical development. Focusing on molecular interactions with GC pathways, particularly the NF-κB, PI3K/Akt, and Wnt/β-catenin pathways, we examined the effects of TCM polyherbal formulas, extracts, and isolated compounds. These agents modulate apoptosis and cellular proliferation, underscoring their potential in preventive strategies. The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework. This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention. The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.
KW - Food chemistry
KW - Gastric cancer
KW - Molecular network
KW - Nutraceuticals
KW - Phytochemistry
KW - Precision medicine
KW - Traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=85203665069&partnerID=8YFLogxK
UR - https://www.wjgnet.com/1948-5204/full/v16/i9/3798.htm
U2 - 10.4251/wjgo.v16.i9.3798
DO - 10.4251/wjgo.v16.i9.3798
M3 - Journal article
AN - SCOPUS:85203665069
SN - 1948-5204
VL - 16
SP - 3798
EP - 3819
JO - World Journal of Gastrointestinal Oncology
JF - World Journal of Gastrointestinal Oncology
IS - 9
ER -
