Matched Molecular Pair Analysis in Drug Discovery: Methods and Recent Applications

Ziyi Yang, Shaohua Shi, Li Fu, Aiping Lu, Tingjun Hou*, Dongsheng Cao*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)


Matched molecular pair analysis (MMPA) is a tool to extract knowledge of medicinal chemistry from existing experimental data, and it relates changes in activities or properties to specific structural changes. More recently, MMPA has also been applied in multi-objective optimization and de novo drug design. Here, we discuss the concept, techniques, and case studies of MMPA, which provide an overview of the current development in the field of MMPA. This Perspective also summarizes up-to-date MMPA applications and highlights the successes and opportunities for further MMPA advances.

Original languageEnglish
Pages (from-to)4361-4377
Number of pages17
JournalJournal of Medicinal Chemistry
Issue number7
Early online date4 Apr 2023
Publication statusPublished - 13 Apr 2023

Scopus Subject Areas

  • Molecular Medicine
  • Drug Discovery


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