Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter

Xin Diao; Chengyi Xie; Guangshan Xie; Yuanyuan Song; Yanshan Liang; Ruijin Li; Chuan Dong; Lin Zhu; Jianing Wang; Zongwei Cai

doi:10.1021/acs.estlett.2c00615

Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter

Xin Diao, Chengyi Xie, Guangshan Xie, Yuanyuan Song, Yanshan Liang, Ruijin Li, Chuan Dong, Lin Zhu^*, Jianing Wang^*, Zongwei Cai^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

4 Citations (Scopus)

Abstract

Fine particulate matter (PM2.5) exposure remains a great health risk worldwide. Epidemiological evidence suggests a possible association between neurodegeneration and PM2.5 exposure. In the present study, cutting-edge mass spectrometry imaging techniques were implemented to investigate the spatial distribution of lipids in rat brains after real ambient exposure to air with high PM2.5 levels. For the first time, a significant reduction of sulfatides in the brain stem and corpus callosum of PM-exposed rats was observed. Further validation using isolated corpus callosum tissues showed that in addition to decreased sulfatides expression levels of neuroinflammation markers including cytokines, microglial, and astrocyte activation markers were significantly upregulated in the PM-exposure group. Our data, therefore, provides a possible association between PM exposure and neurological damage, via sulfatides reduction and associated neuroinflammation in the corpus callosum region of PM-exposed rat brains.

Original language	English
Pages (from-to)	856-862
Number of pages	7
Journal	Environmental Science and Technology Letters
Volume	9
Issue number	10
Early online date	20 Sept 2022
DOIs	https://doi.org/10.1021/acs.estlett.2c00615
Publication status	Published - 11 Oct 2022

Scopus Subject Areas

Environmental Chemistry
Ecology
Water Science and Technology
Waste Management and Disposal
Pollution
Health, Toxicology and Mutagenesis

User-Defined Keywords

MALDI-MSI
Neurodegeneration
Neuroinflammation
Sulfatides
PM2.5

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.estlett.2c00615

Cite this

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title = "Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter",

abstract = "Fine particulate matter (PM2.5) exposure remains a great health risk worldwide. Epidemiological evidence suggests a possible association between neurodegeneration and PM2.5 exposure. In the present study, cutting-edge mass spectrometry imaging techniques were implemented to investigate the spatial distribution of lipids in rat brains after real ambient exposure to air with high PM2.5 levels. For the first time, a significant reduction of sulfatides in the brain stem and corpus callosum of PM-exposed rats was observed. Further validation using isolated corpus callosum tissues showed that in addition to decreased sulfatides expression levels of neuroinflammation markers including cytokines, microglial, and astrocyte activation markers were significantly upregulated in the PM-exposure group. Our data, therefore, provides a possible association between PM exposure and neurological damage, via sulfatides reduction and associated neuroinflammation in the corpus callosum region of PM-exposed rat brains. ",

keywords = "MALDI-MSI, Neurodegeneration, Neuroinflammation, Sulfatides, PM2.5",

author = "Xin Diao and Chengyi Xie and Guangshan Xie and Yuanyuan Song and Yanshan Liang and Ruijin Li and Chuan Dong and Lin Zhu and Jianing Wang and Zongwei Cai",

note = "Funding Information: The authors would like to acknowledge the funding support from the National Natural Science Foundation of China (21705137), National Key Research and Development Program of China (2018YFA0901100), collaborative research fund (C2011-21GF) of the Research Grants Council, Hong Kong Special Administrative Region, China, and a donation from Kwok Chung Bo Fun Charitable Fund for the establishment of the Kwok Yat Wai Endowed Chair of Environmental and Biological Analysis. Publisher Copyright: {\textcopyright} 2022 American Chemical Society",

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doi = "10.1021/acs.estlett.2c00615",

language = "English",

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T1 - Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter

AU - Diao, Xin

AU - Xie, Chengyi

AU - Xie, Guangshan

AU - Song, Yuanyuan

AU - Liang, Yanshan

AU - Li, Ruijin

AU - Dong, Chuan

AU - Zhu, Lin

AU - Wang, Jianing

AU - Cai, Zongwei

N1 - Funding Information: The authors would like to acknowledge the funding support from the National Natural Science Foundation of China (21705137), National Key Research and Development Program of China (2018YFA0901100), collaborative research fund (C2011-21GF) of the Research Grants Council, Hong Kong Special Administrative Region, China, and a donation from Kwok Chung Bo Fun Charitable Fund for the establishment of the Kwok Yat Wai Endowed Chair of Environmental and Biological Analysis. Publisher Copyright: © 2022 American Chemical Society

PY - 2022/10/11

Y1 - 2022/10/11

N2 - Fine particulate matter (PM2.5) exposure remains a great health risk worldwide. Epidemiological evidence suggests a possible association between neurodegeneration and PM2.5 exposure. In the present study, cutting-edge mass spectrometry imaging techniques were implemented to investigate the spatial distribution of lipids in rat brains after real ambient exposure to air with high PM2.5 levels. For the first time, a significant reduction of sulfatides in the brain stem and corpus callosum of PM-exposed rats was observed. Further validation using isolated corpus callosum tissues showed that in addition to decreased sulfatides expression levels of neuroinflammation markers including cytokines, microglial, and astrocyte activation markers were significantly upregulated in the PM-exposure group. Our data, therefore, provides a possible association between PM exposure and neurological damage, via sulfatides reduction and associated neuroinflammation in the corpus callosum region of PM-exposed rat brains.

AB - Fine particulate matter (PM2.5) exposure remains a great health risk worldwide. Epidemiological evidence suggests a possible association between neurodegeneration and PM2.5 exposure. In the present study, cutting-edge mass spectrometry imaging techniques were implemented to investigate the spatial distribution of lipids in rat brains after real ambient exposure to air with high PM2.5 levels. For the first time, a significant reduction of sulfatides in the brain stem and corpus callosum of PM-exposed rats was observed. Further validation using isolated corpus callosum tissues showed that in addition to decreased sulfatides expression levels of neuroinflammation markers including cytokines, microglial, and astrocyte activation markers were significantly upregulated in the PM-exposure group. Our data, therefore, provides a possible association between PM exposure and neurological damage, via sulfatides reduction and associated neuroinflammation in the corpus callosum region of PM-exposed rat brains.

KW - MALDI-MSI

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KW - Neuroinflammation

KW - Sulfatides

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DO - 10.1021/acs.estlett.2c00615

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Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter

Abstract

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