Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter

Xin Diao, Chengyi Xie, Guangshan Xie, Yuanyuan Song, Yanshan Liang, Ruijin Li, Chuan Dong, Lin Zhu*, Jianing Wang*, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)

Abstract

Fine particulate matter (PM2.5) exposure remains a great health risk worldwide. Epidemiological evidence suggests a possible association between neurodegeneration and PM2.5 exposure. In the present study, cutting-edge mass spectrometry imaging techniques were implemented to investigate the spatial distribution of lipids in rat brains after real ambient exposure to air with high PM2.5 levels. For the first time, a significant reduction of sulfatides in the brain stem and corpus callosum of PM-exposed rats was observed. Further validation using isolated corpus callosum tissues showed that in addition to decreased sulfatides expression levels of neuroinflammation markers including cytokines, microglial, and astrocyte activation markers were significantly upregulated in the PM-exposure group. Our data, therefore, provides a possible association between PM exposure and neurological damage, via sulfatides reduction and associated neuroinflammation in the corpus callosum region of PM-exposed rat brains.

Original languageEnglish
Pages (from-to)856-862
Number of pages7
JournalEnvironmental Science and Technology Letters
Volume9
Issue number10
Early online date20 Sept 2022
DOIs
Publication statusPublished - 11 Oct 2022

Scopus Subject Areas

  • Environmental Chemistry
  • Ecology
  • Water Science and Technology
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • MALDI-MSI
  • Neurodegeneration
  • Neuroinflammation
  • Sulfatides
  • PM2.5

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