Mass spectrometry-derived systems biology technologies delineate the system's biochemical applications of siderophores.

Qiao Su, Guang Xu, Tianbing Guan, Yumei Que, Haitao Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)

Abstract

Siderophores are chemically diverse secondary metabolites that primarily assist the host organisms to chelate iron. Siderophores are biosynthesized by many biological organisms, including bacteria, fungi, and plants and they are responsible for a variety of biological functions beyond capture iron. Thus, they could provide a novel understanding of host-pathogen interactions, plant physiology, disease pathogenesis, and drug development. However, knowledge gaps in analytical technologies, chemistry, and biology have severely impeded the applications of siderophores, and a new strategy is urgently needed to bridge these gaps. Mass spectrometry (MS) and associated technologies render unparalleled advantages in this niche in terms of high throughput, resolution, and sensitivity. Herein, this critical review briefly summarizes progress in the study of siderophores and specifically identifies MS-based novel strategies that attempt to mimic the complexity of siderophore systems in order to increase the applicability of these compounds in the scientific community.
Original languageEnglish
Pages (from-to)188-201
Number of pages13
JournalMass Spectrometry Reviews
Volume37
Issue number2
Early online date31 Aug 2016
DOIs
Publication statusPublished - Mar 2018

User-Defined Keywords

  • biological applications
  • biology
  • chemistry
  • mass spectrometry
  • omics techniques
  • siderophores

Fingerprint

Dive into the research topics of 'Mass spectrometry-derived systems biology technologies delineate the system's biochemical applications of siderophores.'. Together they form a unique fingerprint.

Cite this