Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Jianing Wang; Chunyan Wang; Xianlin Han

doi:10.1007/978-3-030-51652-9_3

Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Jianing Wang
, Chunyan Wang
, Xianlin Han^*

^*Corresponding author for this work

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

7 Citations (Scopus)

Abstract

Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

Original language	English
Title of host publication	Cancer Metabolomics
Subtitle of host publication	Methods and Applications
Publisher	Springer Cham
Chapter	3
Pages	39-55
Number of pages	17
Edition	1st
ISBN (Electronic)	9783030516529
ISBN (Print)	9783030516512
DOIs	https://doi.org/10.1007/978-3-030-51652-9_3
Publication status	Published - 1 Apr 2021

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1280
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Cancer lipidomics
Direct infusion-based shotgun lipidomics
Imaging lipidomics
Mass spectrometry
Shotgun lipidomics

Access to Document

10.1007/978-3-030-51652-9_3

Cite this

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title = "Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research",

abstract = "Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.",

keywords = "Cancer lipidomics, Direct infusion-based shotgun lipidomics, Imaging lipidomics, Mass spectrometry, Shotgun lipidomics",

author = "Jianing Wang and Chunyan Wang and Xianlin Han",

note = "Funding Information: aThe full name of abbreviations can be found in the list of acronyms Acknowledgments This work was partially supported by NIH/NIA (RF1 AG061872), intramural institutional research funds from the University of Texas Health Science Center at San Antonio (UT Health SA), the Mass Spectrometry Core Facility of UT Health SA, and the Methodist Hospital Foundation endowment. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",

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doi = "10.1007/978-3-030-51652-9\_3",

language = "English",

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series = "Advances in Experimental Medicine and Biology",

publisher = "Springer Cham",

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T1 - Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

AU - Wang, Jianing

AU - Wang, Chunyan

AU - Han, Xianlin

N1 - Funding Information: aThe full name of abbreviations can be found in the list of acronyms Acknowledgments This work was partially supported by NIH/NIA (RF1 AG061872), intramural institutional research funds from the University of Texas Health Science Center at San Antonio (UT Health SA), the Mass Spectrometry Core Facility of UT Health SA, and the Methodist Hospital Foundation endowment. Publisher Copyright: © 2021, Springer Nature Switzerland AG.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

AB - Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

KW - Cancer lipidomics

KW - Direct infusion-based shotgun lipidomics

KW - Imaging lipidomics

KW - Mass spectrometry

KW - Shotgun lipidomics

UR - https://www.scopus.com/pages/publications/85103642428

U2 - 10.1007/978-3-030-51652-9_3

DO - 10.1007/978-3-030-51652-9_3

M3 - Chapter

C2 - 33791973

AN - SCOPUS:85103642428

SN - 9783030516512

T3 - Advances in Experimental Medicine and Biology

SP - 39

EP - 55

BT - Cancer Metabolomics

PB - Springer Cham

ER -

Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Abstract

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