Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Jianing Wang, Chunyan Wang, Xianlin Han*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

6 Citations (Scopus)

Abstract

Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

Original languageEnglish
Title of host publicationCancer Metabolomics
Subtitle of host publicationMethods and Applications
PublisherSpringer Cham
Chapter3
Pages39-55
Number of pages17
Edition1st
ISBN (Electronic)9783030516529
ISBN (Print)9783030516512
DOIs
Publication statusPublished - 1 Apr 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1280
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

User-Defined Keywords

  • Cancer lipidomics
  • Direct infusion-based shotgun lipidomics
  • Imaging lipidomics
  • Mass spectrometry
  • Shotgun lipidomics

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