Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Jianing WANG, Chunyan Wang, Xianlin Han*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

Abstract

Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages39-55
Number of pages17
DOIs
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1280
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)

User-Defined Keywords

  • Cancer lipidomics
  • Direct infusion-based shotgun lipidomics
  • Imaging lipidomics
  • Mass spectrometry
  • Shotgun lipidomics

Fingerprint

Dive into the research topics of 'Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research'. Together they form a unique fingerprint.

Cite this