Mass Spectrometry-based Proteomics and Glycoproteomics in COVID-19 Biomarkers Identification: A Mini-review

Li Zhong, Lin Zhu*, Zong-Wei Cai

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


The first corona-pandemic, coronavirus disease 2019 (COVID-19) caused a huge health crisis and incalculable damage worldwide. Knowledge of how to cure the disease is urgently needed. Emerging immune escaping mutants of the virus suggested that it may be potentially persistent in human society as a regular health threat as the flu virus. Therefore, it is imperative to identify appropriate biomarkers to indicate pathological and physiological states, and more importantly, clinic outcomes. Proteins are the performers of life functions, and their abundance and modification status can directly reflect the immune status. Protein glycosylation serves a great impact in modulating protein function. The use of both unmodified and glycosylated proteins as biomarkers has also been proved feasible in the studies of SARS, Zika virus, influenza, etc. In recent years, mass spectrometry-based glycoproteomics, as well as proteomics approaches, advanced significantly due to the evolution of mass spectrometry. We focus on the current development of the mass spectrometry-based strategy for COVID-19 biomarkers’ investigation. Potential application of glycoproteomics approaches and challenges in biomarkers identification are also discussed.

Original languageEnglish
Pages (from-to)298-313
Number of pages16
JournalJournal of Analysis and Testing
Issue number4
Early online date8 Sept 2021
Publication statusPublished - Dec 2021

Scopus Subject Areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Instrumentation
  • Spectroscopy
  • Electrochemistry
  • Materials Chemistry

User-Defined Keywords

  • Biomarker
  • COVID-19
  • Glycoproteomics
  • Proteomics
  • SARS-CoV-2


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