TY - JOUR
T1 - Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- And Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China
AU - Lu, Yao
AU - Gao, Ke
AU - Li, Xiaona
AU - Tang, Zhi
AU - Xiang, Li
AU - Zhao, Hongzhi
AU - Fu, Jianjie
AU - Wang, Ling
AU - Zhu, Nali
AU - Cai, Zongwei
AU - Liang, Yong
AU - Wang, Yawei
AU - Jiang, Guibin
N1 - Funding Information:
We thank the National Natural Science Foundation of China (21625702, 21621064, and 21607170), the National Basic Research Program of China (2015CB453102), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB14010400), and Sanming Project of Medicine in Shenzhen (No. SZSM201811070) for financial support.
Publisher copyright:
© 2019 American Chemical Society
PY - 2019/8/20
Y1 - 2019/8/20
N2 - Occupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared to the general population. Herein, 40 occupational workers from a factory in China and 52 control subjects from the general population were involved in an investigation on the potential health concerns of occupational exposure to PFASs by mass spectrometry-based metabolomics analysis. The PFAS levels in plasma from both groups were analyzed. Six PFAS congeners (ς6PFASs) were found to be the main components of the 13 detected PFASs, with a geometric mean of 1770 and 22.2 ng mL-1 in occupational workers and the general population, respectively. Metabolic profiles of the plasma samples were acquired using liquid chromatography coupled with orbitrap high-resolution mass spectrometry and gas chromatography-mass spectrometry. The partial least-squares-discriminant analysis model indicated that the plasma metabolic profiles of the two groups could be clearly separated. Differential and correlation analyses were applied to discover potential biomarkers. A total of 14 potential biomarkers were identified, and they were found to be associated with oxidative stress, fatty acid β-oxidation disorder, and kidney injury. The obtained results indicated that the health effects of occupational exposure to PFASs on workers should not be ignored.
AB - Occupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared to the general population. Herein, 40 occupational workers from a factory in China and 52 control subjects from the general population were involved in an investigation on the potential health concerns of occupational exposure to PFASs by mass spectrometry-based metabolomics analysis. The PFAS levels in plasma from both groups were analyzed. Six PFAS congeners (ς6PFASs) were found to be the main components of the 13 detected PFASs, with a geometric mean of 1770 and 22.2 ng mL-1 in occupational workers and the general population, respectively. Metabolic profiles of the plasma samples were acquired using liquid chromatography coupled with orbitrap high-resolution mass spectrometry and gas chromatography-mass spectrometry. The partial least-squares-discriminant analysis model indicated that the plasma metabolic profiles of the two groups could be clearly separated. Differential and correlation analyses were applied to discover potential biomarkers. A total of 14 potential biomarkers were identified, and they were found to be associated with oxidative stress, fatty acid β-oxidation disorder, and kidney injury. The obtained results indicated that the health effects of occupational exposure to PFASs on workers should not be ignored.
UR - http://www.scopus.com/inward/record.url?scp=85071702620&partnerID=8YFLogxK
U2 - 10.1021/acs.est.9b01608
DO - 10.1021/acs.est.9b01608
M3 - Journal article
C2 - 31246438
AN - SCOPUS:85071702620
SN - 0013-936X
VL - 53
SP - 9800
EP - 9809
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 16
ER -