Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton

Quan-Bin Han; Susan Cheung; Joseph Tai; Chun-Feng Qiao; Jing-Zheng Song; Ting-Fai Tso; Han-Dong Sun; Hong-Xi Xu

doi:10.1021/ol061757j

Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton

Quan-Bin Han
, Susan Cheung
, Joseph Tai
, Chun-Feng Qiao
, Jing-Zheng Song
, Ting-Fai Tso
, Han-Dong Sun
, Hong-Xi Xu

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

51 Citations (Scopus)

Abstract

(Chemical Equation Presented) A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC50 = 2.90, 1.63, and 1.45 μg/mL and with camptothecin and paclitaxel as the positive controls.

Original language	English
Pages (from-to)	4727 - 4730
Journal	Organic Letters
Volume	8
Issue number	21
DOIs	https://doi.org/10.1021/ol061757j
Publication status	Published - Oct 2006

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@article{0de8e8d50e05487fb7ce585bf4c29790,

title = "Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton",

abstract = "(Chemical Equation Presented) A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC50 = 2.90, 1.63, and 1.45 μg/mL and with camptothecin and paclitaxel as the positive controls. ",

author = "Quan-Bin Han and Susan Cheung and Joseph Tai and Chun-Feng Qiao and Jing-Zheng Song and Ting-Fai Tso and Han-Dong Sun and Hong-Xi Xu",

note = "This research is funded by the Hong Kong Jockey Club Charities Trust and partly supported by the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.). ",

year = "2006",

month = oct,

doi = "10.1021/ol061757j",

language = "English",

volume = "8",

pages = "4727 -- 4730",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "21",

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TY - JOUR

T1 - Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton

AU - Han, Quan-Bin

AU - Cheung, Susan

AU - Tai, Joseph

AU - Qiao, Chun-Feng

AU - Song, Jing-Zheng

AU - Tso, Ting-Fai

AU - Sun, Han-Dong

AU - Xu, Hong-Xi

N1 - This research is funded by the Hong Kong Jockey Club Charities Trust and partly supported by the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.).

PY - 2006/10

Y1 - 2006/10

N2 - (Chemical Equation Presented) A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC50 = 2.90, 1.63, and 1.45 μg/mL and with camptothecin and paclitaxel as the positive controls.

AB - (Chemical Equation Presented) A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC50 = 2.90, 1.63, and 1.45 μg/mL and with camptothecin and paclitaxel as the positive controls.

UR - https://www.scopus.com/pages/publications/33750291181

U2 - 10.1021/ol061757j

DO - 10.1021/ol061757j

M3 - Journal article

SN - 1523-7060

VL - 8

SP - 4727

EP - 4730

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton

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