Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton

Quan-Bin Han, Susan Cheung, Joseph Tai, Chun-Feng Qiao, Jing-Zheng Song, Ting-Fai Tso, Han-Dong Sun, Hong-Xi Xu

Research output: Contribution to journalJournal articlepeer-review

47 Citations (Scopus)

Abstract

(Chemical Equation Presented) A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC50 = 2.90, 1.63, and 1.45 μg/mL and with camptothecin and paclitaxel as the positive controls.
Original languageEnglish
Pages (from-to)4727 - 4730
JournalOrganic Letters
Volume8
Issue number21
DOIs
Publication statusPublished - Oct 2006

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