Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara

Sheng Hong Li; Jia Wang; Xue Mei Niu; Yun Heng Shen; Hong Jie Zhang; Han Dong Sun; Ma Lin Li; Qin E. Tian; Yang Lu; Peng Cao; Qi Tai Zheng

doi:10.1021/ol0481535

Maoecrystal V, cytotoxic diterpenoid with a novel C₁₉ skeleton from Isodon eriocalyx (Dunn.) hara

Sheng Hong Li, Jia Wang, Xue Mei Niu, Yun Heng Shen, Hong Jie Zhang, Han Dong Sun^*, Ma Lin Li, Qin E. Tian, Yang Lu, Peng Cao, Qi Tai Zheng

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

134 Citations (Scopus)

Abstract

(Chemical Equation Presented) Maoecrystal V (1), a novel C₁₉ diterpenoid possessing a unique 6,7-seco-6-nor-15(8→9)-abeo-5,8-epoxy-ent- kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC ₅₀ = 0.02 μg/mL (cis-platin: IC₅₀ = 0.99 μg/mL).

Original language	English
Pages (from-to)	4327-4330
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	23
Early online date	20 Oct 2004
DOIs	https://doi.org/10.1021/ol0481535
Publication status	Published - 1 Nov 2004

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title = "Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara",

abstract = "(Chemical Equation Presented) Maoecrystal V (1), a novel C19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8→9)-abeo-5,8-epoxy-ent- kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC 50 = 0.02 μg/mL (cis-platin: IC50 = 0.99 μg/mL).",

author = "Li, {Sheng Hong} and Jia Wang and Niu, {Xue Mei} and Shen, {Yun Heng} and Zhang, {Hong Jie} and Sun, {Han Dong} and Li, {Ma Lin} and Tian, {Qin E.} and Yang Lu and Peng Cao and Zheng, {Qi Tai}",

note = "This project was supported by the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2003RC07, awarded to Dr. Sheng Hong Li).",

year = "2004",

month = nov,

day = "1",

doi = "10.1021/ol0481535",

language = "English",

volume = "6",

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journal = "Organic Letters",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara

AU - Li, Sheng Hong

AU - Wang, Jia

AU - Niu, Xue Mei

AU - Shen, Yun Heng

AU - Zhang, Hong Jie

AU - Sun, Han Dong

AU - Li, Ma Lin

AU - Tian, Qin E.

AU - Lu, Yang

AU - Cao, Peng

AU - Zheng, Qi Tai

N1 - This project was supported by the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2003RC07, awarded to Dr. Sheng Hong Li).

PY - 2004/11/1

Y1 - 2004/11/1

N2 - (Chemical Equation Presented) Maoecrystal V (1), a novel C19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8→9)-abeo-5,8-epoxy-ent- kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC 50 = 0.02 μg/mL (cis-platin: IC50 = 0.99 μg/mL).

AB - (Chemical Equation Presented) Maoecrystal V (1), a novel C19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8→9)-abeo-5,8-epoxy-ent- kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC 50 = 0.02 μg/mL (cis-platin: IC50 = 0.99 μg/mL).

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JO - Organic Letters

JF - Organic Letters

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Maoecrystal V, cytotoxic diterpenoid with a novel C₁₉ skeleton from Isodon eriocalyx (Dunn.) hara

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