(Chemical Equation Presented) Maoecrystal V (1), a novel C19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8→9)-abeo-5,8-epoxy-ent- kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC 50 = 0.02 μg/mL (cis-platin: IC50 = 0.99 μg/mL).
Scopus Subject Areas
- Physical and Theoretical Chemistry
- Organic Chemistry