Malignant gangliocytic paraganglioma of the duodenum with distant metastases and a lethal course

Bin Li, Yang Li, Xiao Ying TIAN, Bo Ning Luo, Zhi Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Gangliocytic paraganglioma (GP) is rare and has been regarded as benign in general with a good prognosis. We present a patient with duodenal GP showing a malignant and lethal clinical course. A 47-year-old male patient was found to have a duodenal tumor and enlarged regional lymph nodes. The patient initially underwent a pancreaticoduodenectomy to resect the tumor and involved lymph nodes completely. Histological and immunohistochemical analyses showed findings typical of GP. However, the distant metastatic lesions in the liver and pelvic cavity were rapidly observed after surgery. The patient underwent chemotherapy and radiotherapy, as well as a second surgery to partly remove the metastatic mass in the pelvic cavity. The histological examination revealed no significant difference in histological features between the primary duodenal tumor and the metastatic pelvic mass. However, the patient finally died of the tumor due to the recurrence of the residual pelvic lesion and increased liver mass. To our knowledge, this is the first report of lethal GP with multifocal metastases. Our case confirms that GP should be regarded as a malignant potential tumor with behavior code of "1", rather than a benign tumor of "0".

Original languageEnglish
Pages (from-to)15454-15461
Number of pages8
JournalWorld Journal of Gastroenterology
Volume20
Issue number41
DOIs
Publication statusPublished - 7 Nov 2014

Scopus Subject Areas

  • Gastroenterology

User-Defined Keywords

  • Duodenal neoplasms
  • Gangliocytic neoplasms
  • Lymphatic metastasis
  • Paraganglioma
  • Treatment outcome

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