MALDI-TOF-MS for rapid screening analysis of M-protein in serum

Jie Li*, Anping Xu, Weijie Xie, Bowen Li, Cunliang Yan, Yong Xia, Chao Liang*, Ling Ji*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)

Abstract

Monoclonal immunoglobin (M-protein) is a serum biomarker for the diagnosis of plasma cell dyscrasias. Despite limitation of analytical sensitivity and resolution, serum protein electrophoresis and immunofixation electrophoresis are still the front-line tests for the detection of M-proteins. Herein, we developed a MALDI-TOF Mass spectrometry-based method for the screening test of M-proteins in human serum. Based on the unique mass signature of different immunoglobin isotypes, M-Proteins could be rapidly identified and typed. The method demonstrated with high analytical performance and throughput, rapid and simple, which could be a new choice for the diagnosis of plasma cell dyscrasias.

Original languageEnglish
Article number1073479
Number of pages8
JournalFrontiers in Oncology
Volume12
DOIs
Publication statusPublished - 15 Dec 2022

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • M-protein
  • MALDI-TOF-MS
  • plasma cell dyscrasias
  • screening test
  • serum

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