Abstract
Monoclonal immunoglobin (M-protein) is a serum biomarker for the diagnosis of plasma cell dyscrasias. Despite limitation of analytical sensitivity and resolution, serum protein electrophoresis and immunofixation electrophoresis are still the front-line tests for the detection of M-proteins. Herein, we developed a MALDI-TOF Mass spectrometry-based method for the screening test of M-proteins in human serum. Based on the unique mass signature of different immunoglobin isotypes, M-Proteins could be rapidly identified and typed. The method demonstrated with high analytical performance and throughput, rapid and simple, which could be a new choice for the diagnosis of plasma cell dyscrasias.
Original language | English |
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Article number | 1073479 |
Number of pages | 8 |
Journal | Frontiers in Oncology |
Volume | 12 |
DOIs | |
Publication status | Published - 15 Dec 2022 |
Scopus Subject Areas
- Oncology
- Cancer Research
User-Defined Keywords
- M-protein
- MALDI-TOF-MS
- plasma cell dyscrasias
- screening test
- serum