Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

Nengxuan Ma; Lin Zhang; Ruijin Li; Yehong Zhou; Zongwei CAI; Chuan Dong; Shaomin Shuang

doi:10.1039/c4ay00768a

Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe₃O₄/SiO₂ composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

Nengxuan Ma, Lin Zhang, Ruijin Li, Yehong Zhou, Zongwei CAI, Chuan Dong, Shaomin Shuang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

7 Citations (Scopus)

Abstract

A novel trimethylstearylammonium bromide (TSAB) coated Fe₃O ₄/SiO₂ magnetic nanocomposite was fabricated and used as the adsorbent for the magnetic solid-phase extraction of adriamycin hydrochloride (ADR) in human plasma and urine with high performance liquid chromatography-fluorescence detection (HPLC-FLD). The factors influencing the extraction efficiency were examined including the pH value, extraction time, elution solvent, etc. A good linearity was presented by HPLC-FLD in the range of 0.5-10.0 μg mL^-1 for ADR, with the correlation coefficient of 0.998 (R²). The relative standard deviation was 4.27%. The limit of detection and limit of quantitation were 5.05 and 16.82 ng mL^-1, respectively. The feasibility of the developed method was further validated by extraction of ADR in plasma and urine samples. The recoveries were in the range of 76.5-94.0% and 77.9-96.0% for plasma and urine samples, respectively. This journal is

Original language	English
Pages (from-to)	6736-6744
Number of pages	9
Journal	Analytical Methods
Volume	6
Issue number	17
DOIs	https://doi.org/10.1039/c4ay00768a
Publication status	Published - 7 Sept 2014

Scopus Subject Areas

Analytical Chemistry
Chemical Engineering(all)
Engineering(all)

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title = "Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD",

abstract = "A novel trimethylstearylammonium bromide (TSAB) coated Fe3O 4/SiO2 magnetic nanocomposite was fabricated and used as the adsorbent for the magnetic solid-phase extraction of adriamycin hydrochloride (ADR) in human plasma and urine with high performance liquid chromatography-fluorescence detection (HPLC-FLD). The factors influencing the extraction efficiency were examined including the pH value, extraction time, elution solvent, etc. A good linearity was presented by HPLC-FLD in the range of 0.5-10.0 μg mL-1 for ADR, with the correlation coefficient of 0.998 (R2). The relative standard deviation was 4.27%. The limit of detection and limit of quantitation were 5.05 and 16.82 ng mL-1, respectively. The feasibility of the developed method was further validated by extraction of ADR in plasma and urine samples. The recoveries were in the range of 76.5-94.0% and 77.9-96.0% for plasma and urine samples, respectively. This journal is",

author = "Nengxuan Ma and Lin Zhang and Ruijin Li and Yehong Zhou and Zongwei CAI and Chuan Dong and Shaomin Shuang",

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doi = "10.1039/c4ay00768a",

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Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe₃O₄/SiO₂ composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD. / Ma, Nengxuan; Zhang, Lin; Li, Ruijin et al.
In: Analytical Methods, Vol. 6, No. 17, 07.09.2014, p. 6736-6744.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

AU - Ma, Nengxuan

AU - Zhang, Lin

AU - Li, Ruijin

AU - Zhou, Yehong

AU - CAI, Zongwei

AU - Dong, Chuan

AU - Shuang, Shaomin

PY - 2014/9/7

Y1 - 2014/9/7

N2 - A novel trimethylstearylammonium bromide (TSAB) coated Fe3O 4/SiO2 magnetic nanocomposite was fabricated and used as the adsorbent for the magnetic solid-phase extraction of adriamycin hydrochloride (ADR) in human plasma and urine with high performance liquid chromatography-fluorescence detection (HPLC-FLD). The factors influencing the extraction efficiency were examined including the pH value, extraction time, elution solvent, etc. A good linearity was presented by HPLC-FLD in the range of 0.5-10.0 μg mL-1 for ADR, with the correlation coefficient of 0.998 (R2). The relative standard deviation was 4.27%. The limit of detection and limit of quantitation were 5.05 and 16.82 ng mL-1, respectively. The feasibility of the developed method was further validated by extraction of ADR in plasma and urine samples. The recoveries were in the range of 76.5-94.0% and 77.9-96.0% for plasma and urine samples, respectively. This journal is

AB - A novel trimethylstearylammonium bromide (TSAB) coated Fe3O 4/SiO2 magnetic nanocomposite was fabricated and used as the adsorbent for the magnetic solid-phase extraction of adriamycin hydrochloride (ADR) in human plasma and urine with high performance liquid chromatography-fluorescence detection (HPLC-FLD). The factors influencing the extraction efficiency were examined including the pH value, extraction time, elution solvent, etc. A good linearity was presented by HPLC-FLD in the range of 0.5-10.0 μg mL-1 for ADR, with the correlation coefficient of 0.998 (R2). The relative standard deviation was 4.27%. The limit of detection and limit of quantitation were 5.05 and 16.82 ng mL-1, respectively. The feasibility of the developed method was further validated by extraction of ADR in plasma and urine samples. The recoveries were in the range of 76.5-94.0% and 77.9-96.0% for plasma and urine samples, respectively. This journal is

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Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe₃O₄/SiO₂ composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

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