TY - JOUR
T1 - Magnetic-NIR Persistent Luminescent Dual-Modal ZGOCS@MSNs@Gd2O3 Core-Shell Nanoprobes for in Vivo Imaging
AU - Zou, Rui
AU - Gong, Shuming
AU - Shi, Junpeng
AU - Jiao, Ju
AU - WONG, Ka-Leung
AU - Zhang, Hongwu
AU - Wang, Jing
AU - Su, Qiang
N1 - Funding Information:
This work was financially supported by the NSFC (51572302 and 21271191), the -973- programs (2014CB643801), the Joint Funds of the National Natural Science Foundation of China and Guangdong Province (U1301242), Teamwork Projects of Guangdong Natural Science Foundation (S2013030012842), Guangdong Science & Technology Project (2013B090800019 and 2015B090926011), and Natural Science Foundation of Guangdong Province (2014A030313114 and 2016A030313241).
PY - 2017/5/9
Y1 - 2017/5/9
N2 - Recently, Gd3+-based NIR persistent luminescence nanoparticles have been proposed as highly promising multimodal nanoprobes for full-scale visualization medical techniques in early diagnosis of cancer. However, they still face with some problems, such as hampering further functionalization for the loss of available surface, shortening plasma half-life of the probe caused by inevitable size increase, and reducing SNR because of significant persistent intensity loss. In this study, a novel core-shell structure Gd3+-based NIR persistent luminescence multimodal probe ZGOCS@MSNs@Gd2O3 for T1-weighted MR imaging and NIR persistent luminescence imaging was successfully synthesized using MSNs as the reaction vessels for ZGOCS nanoparticles and the core for Gd2O3 shell. Compared with previously reported Gd3+-based NIR persistent luminescence-based multimodal nanoprobes, the as-prepared nanoparticles enable surface available, no persistent intensity loss and only a slight size increase. Moreover, this multifunctional nanoprobe not only retains excellent NIR persistent luminescence properties with rechargeable ability, but also possesses high longitudinal relaxivity via the Gd2O3 shell, positioning ZGOCS@MSNs@Gd2O3 as highly promising nanoprobe for future multimodal bioimaging.
AB - Recently, Gd3+-based NIR persistent luminescence nanoparticles have been proposed as highly promising multimodal nanoprobes for full-scale visualization medical techniques in early diagnosis of cancer. However, they still face with some problems, such as hampering further functionalization for the loss of available surface, shortening plasma half-life of the probe caused by inevitable size increase, and reducing SNR because of significant persistent intensity loss. In this study, a novel core-shell structure Gd3+-based NIR persistent luminescence multimodal probe ZGOCS@MSNs@Gd2O3 for T1-weighted MR imaging and NIR persistent luminescence imaging was successfully synthesized using MSNs as the reaction vessels for ZGOCS nanoparticles and the core for Gd2O3 shell. Compared with previously reported Gd3+-based NIR persistent luminescence-based multimodal nanoprobes, the as-prepared nanoparticles enable surface available, no persistent intensity loss and only a slight size increase. Moreover, this multifunctional nanoprobe not only retains excellent NIR persistent luminescence properties with rechargeable ability, but also possesses high longitudinal relaxivity via the Gd2O3 shell, positioning ZGOCS@MSNs@Gd2O3 as highly promising nanoprobe for future multimodal bioimaging.
UR - http://www.scopus.com/inward/record.url?scp=85019143774&partnerID=8YFLogxK
U2 - 10.1021/acs.chemmater.7b00087
DO - 10.1021/acs.chemmater.7b00087
M3 - Article
AN - SCOPUS:85019143774
SN - 0897-4756
VL - 29
SP - 3938
EP - 3946
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 9
ER -