TY - JOUR
T1 - Magnetic microspheres with polydopamine encapsulated ultra-small noble metal nanocrystals as mimetic enzymes for the colorimetric detection of H2O2 and glucose
AU - Bai, Linfeng
AU - Jiang, Wanquan
AU - Sang, Min
AU - Liu, Mei
AU - Xuan, Shouhu
AU - Wang, Sheng
AU - LEUNG, Ken C F
AU - Gong, Xinglong
N1 - Funding Information:
Financial supports from the National Natural Science Foundation of China (Grant No. 11822209, 11572310) and the Strategic Priority Research Program of the Chinese Academy of Sciences Grant No. XDB22040502 are gratefully acknowledged. This study was also supported by the Collaborative Innovation Center of Suzhou Nano Science and Technology.
PY - 2019/8/7
Y1 - 2019/8/7
N2 - The exploitation of multifunctional nanocomposites as artificial mimetic enzymes has received significant attention. This study reports a novel sandwich-structural magnetic microsphere (Fe3O4@resorcinol/formaldehyde resin-metal@polydopamine), in which ultra-small noble metal nanocrystals can be sandwiched between the resorcinol/formaldehyde resin (RF) and polydopamine (PDA) layers. By changing the metal precursor, various microspheres decorated with mono- or bi-metallic nanocrystals (Pt, Pd, Au, PtAu, etc.) can be obtained. The dual-shelled magnetic microsphere not only provides abundant active sites for noble metal nanocrystals but also effectively restrains aggregation and leaching. The as-prepared Fe3O4@RF-Pt@PDA can efficiently catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2, which confirms that the as-prepared nanocatalyst shows good peroxidase-like activity. The catalytic activity of Fe3O4@RF-Pt@PDA is dependent on pH and temperature, and the relevant catalytic kinetics follow the Michaelis-Menten behaviors. Moreover, this kind of magnetic microsphere can be further applied for H2O2 and glucose detections and the limit of detection (LOD) is found to be as low as 3.1 μM and 1.36 μM, respectively. Benefiting from a facile preparation process, superior structure, and outstanding catalytic activity, these multifunctional microspheres possess high potential as artificial enzymes in clinical diagnosis, analytical chemistry and environmental fields.
AB - The exploitation of multifunctional nanocomposites as artificial mimetic enzymes has received significant attention. This study reports a novel sandwich-structural magnetic microsphere (Fe3O4@resorcinol/formaldehyde resin-metal@polydopamine), in which ultra-small noble metal nanocrystals can be sandwiched between the resorcinol/formaldehyde resin (RF) and polydopamine (PDA) layers. By changing the metal precursor, various microspheres decorated with mono- or bi-metallic nanocrystals (Pt, Pd, Au, PtAu, etc.) can be obtained. The dual-shelled magnetic microsphere not only provides abundant active sites for noble metal nanocrystals but also effectively restrains aggregation and leaching. The as-prepared Fe3O4@RF-Pt@PDA can efficiently catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2, which confirms that the as-prepared nanocatalyst shows good peroxidase-like activity. The catalytic activity of Fe3O4@RF-Pt@PDA is dependent on pH and temperature, and the relevant catalytic kinetics follow the Michaelis-Menten behaviors. Moreover, this kind of magnetic microsphere can be further applied for H2O2 and glucose detections and the limit of detection (LOD) is found to be as low as 3.1 μM and 1.36 μM, respectively. Benefiting from a facile preparation process, superior structure, and outstanding catalytic activity, these multifunctional microspheres possess high potential as artificial enzymes in clinical diagnosis, analytical chemistry and environmental fields.
UR - http://www.scopus.com/inward/record.url?scp=85069753419&partnerID=8YFLogxK
U2 - 10.1039/c9tb00755e
DO - 10.1039/c9tb00755e
M3 - Journal article
AN - SCOPUS:85069753419
SN - 2050-750X
VL - 7
SP - 4568
EP - 4580
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 29
ER -