TY - JOUR
T1 - Magnetic iron oxide nanoparticle-hollow mesoporous silica Spheres
T2 - Fabrication and potential application in drug delivery
AU - Teng, Yun
AU - Du, Yimeng
AU - Shi, Jue
AU - Pong, Philip W.T.
N1 - Funding Information:
This research was supported by the Seed Funding Program for Basic Research, Seed Funding Program for Applied Research and Small Project Funding Program from University of Hong Kong, RGC-GRF grant ( HKU 17204617 ), ITF Tier 3 funding ( ITS-104/13 , ITS-214/14 ), and University Grants Committee of HK ( AoE/P-04/08 ).
Publisher Copyright:
© 2019 Korean Physical Society. Published by Elsevier B.V. All rights reserved.
PY - 2020/2
Y1 - 2020/2
N2 - A facile method is developed for the fabrication of magnetic iron oxide nanoparticle-hollow mesoporous silica spheres (IONP-HMSs) and explored their potential application in drug delivery. Through the self-assembling process of IONPs and the formation of mesoporous silica shells, the IONP-HMSs with hollow interior cavity were obtained. The cetyltrimethyl ammonium bromide (CTAB) encapsulated IONP-containing spheres served as the template to establish the mesoporous silica shells. Typical anti-cancer drug, doxorubicin hydrochloride (DOX) was applied for drug loading and release process of IONP-HMSs, which demonstrated the IONP-HMSs have a high drug loading efficiency and allow pH-trigged release of DOX in vitro. Moreover, the IONP-HMSs exhibited excellent biocompatibility and enhanced DOX therapeutic efficacy to HeLa cells. Compared with traditional methods, the reported microemulsion-based method for the synthesis of IONP-HMSs enables the formation of hollow-structured nanocomposite without any complex template-removing process, which could pave the way to improving the therapeutic efficacy in drug delivery system.
AB - A facile method is developed for the fabrication of magnetic iron oxide nanoparticle-hollow mesoporous silica spheres (IONP-HMSs) and explored their potential application in drug delivery. Through the self-assembling process of IONPs and the formation of mesoporous silica shells, the IONP-HMSs with hollow interior cavity were obtained. The cetyltrimethyl ammonium bromide (CTAB) encapsulated IONP-containing spheres served as the template to establish the mesoporous silica shells. Typical anti-cancer drug, doxorubicin hydrochloride (DOX) was applied for drug loading and release process of IONP-HMSs, which demonstrated the IONP-HMSs have a high drug loading efficiency and allow pH-trigged release of DOX in vitro. Moreover, the IONP-HMSs exhibited excellent biocompatibility and enhanced DOX therapeutic efficacy to HeLa cells. Compared with traditional methods, the reported microemulsion-based method for the synthesis of IONP-HMSs enables the formation of hollow-structured nanocomposite without any complex template-removing process, which could pave the way to improving the therapeutic efficacy in drug delivery system.
KW - Adsorption capacity and loading efficiency
KW - Cell viability
KW - Magnetic nanoparticles
KW - Mesoporous silica spheres
KW - pH-triggred release
UR - http://www.scopus.com/inward/record.url?scp=85090256633&partnerID=8YFLogxK
U2 - 10.1016/j.cap.2019.11.012
DO - 10.1016/j.cap.2019.11.012
M3 - Journal article
AN - SCOPUS:85090256633
SN - 1567-1739
VL - 20
SP - 320
EP - 325
JO - Current Applied Physics
JF - Current Applied Physics
IS - 2
ER -
