Magnetic hybrid nanospindle with an unconventional force-thermal coupling antibacterial effect

Jing Wang, Xue Fang, Guangjin Yu*, Tianzhi Luo, Yunqi Xu, Chunyan Xu*, Ken Cham Fai Leung, Ailing Hui, Shouhu Xuan*, Qunling Fang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

Nanoplatforms have been considered as an effective strategy to address the resistance problem of traditional antimicrobial agents. This work reports a magnetic Fe3O4@AgAu@PDA (Fe3O4@AgAu@Polydopamine) antibacterial nanomaterial which possesses magnetically induced force-thermal coupling antibacterial effect. The polydopamine shell has good biocompatibility and the AgAu nanorods immobilized on the surface of the magnetic nanospindle not only create a rough surface for the anisotropic nanospindle but also endow it with high photothermal performance and oxidase-like/peroxide-like activities. Besides the original Ag ions release antibacterial activity, Fe3O4@AgAu@PDA nanospindles (80 μg/mL) also exhibit a good photothermal antibacterial effect (>90%) against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation. Interestingly, when a rotating magnetic field (RMF) is applied, the antibacterial activity of the magnetic nanospindles can be further increased to nearly 100%. More importantly, in comparison to the Fe3O4@AgAu@PDA nanospheres, the Fe3O4@AgAu@PDA nanospindles exhibit a better antibacterial effect. By exploring the interaction between different particles and bacteria under magnetic field conditions, the basic mechanism of force-thermal coupling antibacterial was deeply explored and extended to biofilm removal. The results of cytotoxicity assay show that Fe3O4@AgAu@PDA nanospindles have good biocompatibility. Thus, the proposed strategy provides broad promise in antimicrobial therapy and biomedicine.

Original languageEnglish
Article number133060
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume683
Early online date22 Dec 2023
DOIs
Publication statusPublished - 20 Feb 2024

Scopus Subject Areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

User-Defined Keywords

  • Anisotropic
  • Antibacterial
  • Biofilm
  • Magnetic
  • Photothermal

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