Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma

Bing Liao, Bi Ling Zhong, Zhi Li*, Xiao Ying TIAN, Yang Li, Bin Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Background and Objectives: We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients. Methods One hundred and forty one cases of NPC and 25 normal tissues of nasopharynx were collected. The expression of MIF and interleukin 8 (IL-8) was evaluated in tissues microarray by immunostaining. Intratumoral microvessel density (IMD) in relation to immunostainings and clinicopathological factors were analyzed statistically as well as the follow-up data of patients. Results High-expression of both MIF (69.5%) and IL-8 (56.0%) were significantly associated with increased microvessels and lymph node metastasis. High-expression of MIF, IL-8 and higher level of IMD were correlated with either patients' overall survival or disease-specific survival in univariate analysis, but only angiogenesis and lymph node status exhibited in relation to survival of patients as independent prognostic factor of NPC by multivariate analysis. In addition, high-expression of MIF and higher level of IMD were closely associated with locoregional failure of NPC patients. Conclusions MIF may contribute to lymph node metastasis in NPC by inducing angiogenesis through the way of upregulation of IL-8 expression in an autocrine EBV-independent pathway.

Original languageEnglish
Pages (from-to)844-851
Number of pages8
JournalJournal of Surgical Oncology
Volume102
Issue number7
DOIs
Publication statusPublished - 1 Dec 2010

Scopus Subject Areas

  • Surgery
  • Oncology

User-Defined Keywords

  • angiogenesis
  • Interleukin 8
  • macrophage migration inhibitory factor (MIF)
  • nasopharyngeal carcinoma (NPC)
  • prognosis

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