Machine learning technique reveals intrinsic characteristics of schizophrenia: an alternative method

Junhua Li*, Yu Sun, Yi Huang, Anastasios Bezerianos, Rongjun Yu

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

25 Citations (Scopus)


Machine learning technique has long been utilized to assist disease diagnosis, increasing clinical physicians’ confidence in their decision and expediting the process of diagnosis. In this case, machine learning technique serves as a tool for distinguishing patients from healthy people. Additionally, it can also serve as an exploratory method to reveal intrinsic characteristics of a disease based on discriminative features, which was demonstrated in this study. Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 148 participants (including patients with schizophrenia and healthy controls). Connective strengths were estimated by Pearson correlation for each pair of brain regions partitioned according to automated anatomical labelling atlas. Subsequently, consensus connections with high discriminative power were extracted under the circumstance of the best classification accuracy. Investigating these consensus connections, we found that schizophrenia group predominately exhibited weaker strengths of inter-regional connectivity compared to healthy group. Aberrant connectivities in both intra- and inter-hemispherical connections were observed. Within intra-hemispherical connections, the number of aberrant connections in the right hemisphere was more than that of the left hemisphere. In the exploration of large regions, we revealed that the serious dysconnectivities mainly appeared on temporal and occipital regions for the within-large-region connections; while connectivity disruption was observed on the connections from temporal region to occipital, insula and limbic regions for the between-large-region connections. The findings of this study corroborate previous conclusion of dysconnectivity in schizophrenia and further shed light on distribution patterns of dysconnectivity, which deepens the understanding of pathological mechanism of schizophrenia.

Original languageEnglish
Pages (from-to)1386-1396
Number of pages11
JournalBrain Imaging and Behavior
Issue number5
Publication statusPublished - 1 Oct 2019

Scopus Subject Areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

User-Defined Keywords

  • Functional connectivity
  • Hemispherical distribution of connections
  • Large-region connectivity
  • Resting-state fMRI
  • Schizophrenia


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