Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding

Grace Lai Hung Wong, Andy Jinhua Ma, Huiqi Deng, Jessica Yuet Ling Ching, Vincent Wai Sun Wong, Yee Kit Tse, Terry Cheuk Fung Yip, Louis Ho Shing Lau, Henry Hin Wai Liu, Chi Man Leung, Steven Woon Choy Tsang, Chun Wing Chan, James Yun Wong Lau*, Pong Chi YUEN, Francis Ka Leung Chan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: Patients with a history of Helicobacter pylori–negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications. Aim: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding. Methods: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding. We tested the IPU-ML in all patients with a diagnosis of gastrointestinal bleeding (n = 1265) in 2008-2015 from a different catchment population (independent validation cohort). Any co-morbid conditions which had occurred in >1% of study population were eligible as predictors. Results: Recurrent ulcer bleeding developed in 4772 patients (19.5%) in the training cohort, during a median follow-up period of 2.7 years. IPU-ML model built on six parameters (age, baseline haemoglobin, and presence of gastric ulcer, gastrointestinal diseases, malignancies, and infections) identified patients with bleeding recurrence within 1 year with an area under the receiver operating characteristic curve (AUROC) of 0.648. When we set the IPU-ML cutoff value at 0.20, 27.5% of patients were classified as high risk for rebleeding with a sensitivity of 41.4%, specificity of 74.6%, and a negative predictive value of 91.1%. In the validation cohort, the IPU-ML identified patients with a recurrence ulcer bleeding within 1 year with an AUROC of 0.775, and 84.3% of overall accuracy. Conclusion: We developed a machine-learning model to identify those patients with a history of idiopathic gastroduodenal ulcer bleeding who are not at high risk for recurrent ulcer bleeding.

Original languageEnglish
Pages (from-to)912-918
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume49
Issue number7
DOIs
Publication statusPublished - Apr 2019

Scopus Subject Areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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