Lysozyme-stabilized gold nanoclusters as a novel fluorescence probe for cyanide recognition

Dongtao Lu, Lili Liu, Fengxia Li, Shaomin Shuang, Yingfu Li, Martin M F Choi, Chuan Dong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

67 Citations (Scopus)


Lysozyme-stabilized gold nanoclusters (Lys-AuNCs) have been synthesized and utilized as a fluorescent probe for selective detection of cyanide (CN -). Lys-AuNCs had an average size of 4 nm and showed a red emission at 650 nm (λex = 370 nm). The fluorescence of Lys-AuNCs could be quenched by CN-. An excellent sensitivity and selectivity toward the detection of CN- in aqueous solution was observed. The fluorescence intensity was linear with the CN- concentration in the range of 5.00 × 10-6 M-1.20 × 10-4 M with a detection limit as low as 1.9 × 10-7 M. Also, the addition of CN- to Lys-AuNCs could induce an obvious color change from light yellow to colorless. Correspondingly, a bright red fluorescence disappeared and a blue fluorescence appeared. The results indicated that Lys-AuNCs could be applied in detection of cyanide on environmental aspects.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Publication statusPublished - 5 Mar 2014

Scopus Subject Areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy

User-Defined Keywords

  • Cyanide recognition
  • Fluorescence probe
  • Gold nanoclusters


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