Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

Chenfu Liu; Chao Yang; Lihua Lu; Wanhe Wang; Weihong Tan; Chung Hang Leung; Edmond Dik Lung Ma

doi:10.1039/c6cc08109f

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

Chenfu Liu
, Chao Yang
, Lihua Lu
, Wanhe Wang
, Weihong Tan^*
, Chung Hang Leung^*
, Edmond Dik Lung Ma^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

53 Citations (Scopus)

Abstract

Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

Original language	English
Pages (from-to)	2822-2825
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	19
Early online date	16 Jan 2017
DOIs	https://doi.org/10.1039/c6cc08109f
Publication status	Published - 7 Mar 2017

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10.1039/c6cc08109f

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title = "Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells",

abstract = "Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.",

author = "Chenfu Liu and Chao Yang and Lihua Lu and Wanhe Wang and Weihong Tan and Leung, \{Chung Hang\} and Ma, \{Edmond Dik Lung\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/ 03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), and National Natural Science Foundation of China (21628502).",

year = "2017",

month = mar,

day = "7",

doi = "10.1039/c6cc08109f",

language = "English",

volume = "53",

pages = "2822--2825",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

AU - Liu, Chenfu

AU - Yang, Chao

AU - Lu, Lihua

AU - Wang, Wanhe

AU - Tan, Weihong

AU - Leung, Chung Hang

AU - Ma, Edmond Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/ 03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), and National Natural Science Foundation of China (21628502).

PY - 2017/3/7

Y1 - 2017/3/7

N2 - Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

AB - Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

UR - https://www.scopus.com/pages/publications/85014307791

U2 - 10.1039/c6cc08109f

DO - 10.1039/c6cc08109f

M3 - Journal article

C2 - 28127603

AN - SCOPUS:85014307791

SN - 1359-7345

VL - 53

SP - 2822

EP - 2825

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

Abstract

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