Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

  • Chenfu Liu
  • , Chao Yang
  • , Lihua Lu
  • , Wanhe Wang
  • , Weihong Tan*
  • , Chung Hang Leung*
  • , Edmond Dik Lung Ma*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

52 Citations (Scopus)

Abstract

Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

Original languageEnglish
Pages (from-to)2822-2825
Number of pages4
JournalChemical Communications
Volume53
Issue number19
Early online date16 Jan 2017
DOIs
Publication statusPublished - 7 Mar 2017

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