Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

Chenfu LIU, Chao Yang, Lihua Lu, Wanhe Wang, Weihong Tan*, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

Original languageEnglish
Pages (from-to)2822-2825
Number of pages4
JournalChemical Communications
Volume53
Issue number19
DOIs
Publication statusPublished - 2017

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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