Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

Phyllis Kit Man  Siu; Dik Lung Ma; Chi Ming Che

doi:10.1039/b414936j

Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

Phyllis Kit Man Siu
, Dik Lung Ma
, Chi Ming Che^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

99 Citations (Scopus)

Abstract

Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 10⁶ dm³ mol⁻¹) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC₅₀ of up to 1 μM against a number of carcinoma cell lines.

Original language	English
Pages (from-to)	1025-1027
Number of pages	3
Journal	Chemical Communications
Issue number	8
DOIs	https://doi.org/10.1039/b414936j
Publication status	Published - 28 Feb 2005

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10.1039/b414936j

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@article{46703afd4c53413ba2b9d603574d0da4,

title = "Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding",

abstract = "Pt(C\textasciicircum{}N)(phe) (1, C\textasciicircum{}N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C\textasciicircum{}N)(phe) (1), Pt(C\textasciicircum{}N)(trp) (2, trp = tryptophan) and Pt(C\textasciicircum{}N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.",

author = "Siu, \{Phyllis Kit Man\} and Ma, \{Dik Lung\} and Che, \{Chi Ming\}",

note = "Funding information: This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), The University of Hong Kong (University Development Fund) and The University of Hong Kong, Research Grants Council of the Hong Kong SAR, China [HKU 7039/03P]. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2005",

year = "2005",

month = feb,

day = "28",

doi = "10.1039/b414936j",

language = "English",

pages = "1025--1027",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "8",

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TY - JOUR

T1 - Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

AU - Siu, Phyllis Kit Man

AU - Ma, Dik Lung

AU - Che, Chi Ming

N1 - Funding information: This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), The University of Hong Kong (University Development Fund) and The University of Hong Kong, Research Grants Council of the Hong Kong SAR, China [HKU 7039/03P]. Publisher copyright: © The Royal Society of Chemistry 2005

PY - 2005/2/28

Y1 - 2005/2/28

N2 - Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.

AB - Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.

UR - https://www.scopus.com/pages/publications/14944340145

U2 - 10.1039/b414936j

DO - 10.1039/b414936j

M3 - Journal article

C2 - 15719104

AN - SCOPUS:14944340145

SN - 1359-7345

SP - 1025

EP - 1027

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

Abstract

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