Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

Phyllis Kit Man Siu, Dik Lung Ma, Chi Ming Che*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.

Original languageEnglish
Pages (from-to)1025-1027
Number of pages3
JournalChemical Communications
Issue number8
DOIs
Publication statusPublished - 28 Feb 2005
Externally publishedYes

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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