@article{46703afd4c53413ba2b9d603574d0da4,
title = "Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding",
abstract = "Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol−1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines.",
author = "Siu, {Phyllis Kit Man} and Ma, {Dik Lung} and Che, {Chi Ming}",
note = "Funding information: This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), The University of Hong Kong (University Development Fund) and The University of Hong Kong, Research Grants Council of the Hong Kong SAR, China [HKU 7039/03P]. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2005",
year = "2005",
month = feb,
day = "28",
doi = "10.1039/b414936j",
language = "English",
pages = "1025--1027",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "8",
}