Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes

Edmond Dik Lung MA*, Chun Wu, Hao Liu, Ke Jia Wu, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Protein biomarkers, particularly abnormally expressed receptor proteins, have been proved to be one of the crucial biomarkers for the rapid assessment, diagnosis, prognosis and prediction of specific human diseases. Transition metal based strategies in particular possess delightful strengths in the in-field and real-time visualization of receptor proteins owing to their unique photophysical properties. In this review, we highlight recent advances in the development of detection methods for receptor protein biomarkers using transition metal based approaches, particularly those employing transition metal complexes. We first discuss the strengths and weaknesses of various strategies used for protein biomarker monitoring in live cells. We then describe the principles of the various sensing platforms and their application for receptor protein detection. Finally, we discuss the challenges and future inspirations in this specific field.

Original languageEnglish
Pages (from-to)3249-3260
Number of pages12
JournalJournal of Materials Chemistry B
Volume8
Issue number16
DOIs
Publication statusPublished - 28 Apr 2020

Scopus Subject Areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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