Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

Lihua Lu; Chenfu Liu; Guodong Li; Li Juan Liu; Chung Hang Leung; Dik Lung Ma

doi:10.1016/j.snb.2017.11.047

Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

Lihua Lu^*, Chenfu Liu, Guodong Li, Li Juan Liu, Chung Hang Leung, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

11 Citations (Scopus)

Abstract

A novel graphene oxide (GO)-based pH sensor was designed and prepared through covalently attaching a zwitterionic betaine molecule onto a GO surface. This betaine-modified GO (BMGO) exhibited high water solubility and low toxicity. In aqueous media, BMGO displayed increased fluorescence in acidic conditions and decreased fluorescence in basic conditions. BMGO possesses a pH sensing range from 4 to 12 with excellent reversibility, quick response and high stability. With its high sensitivity and robustness, BMGO can be used to monitor the pH of intracellular contents, as demonstrated through cell imaging.

Original language	English
Pages (from-to)	860-865
Number of pages	6
Journal	Sensors and Actuators B: Chemical
Volume	257
DOIs	https://doi.org/10.1016/j.snb.2017.11.047
Publication status	Published - Mar 2018

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

User-Defined Keywords

Betaine
Fluorescent
Graphene oxide
pH sensor

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10.1016/j.snb.2017.11.047

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title = "Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment",

abstract = "A novel graphene oxide (GO)-based pH sensor was designed and prepared through covalently attaching a zwitterionic betaine molecule onto a GO surface. This betaine-modified GO (BMGO) exhibited high water solubility and low toxicity. In aqueous media, BMGO displayed increased fluorescence in acidic conditions and decreased fluorescence in basic conditions. BMGO possesses a pH sensing range from 4 to 12 with excellent reversibility, quick response and high stability. With its high sensitivity and robustness, BMGO can be used to monitor the pH of intracellular contents, as demonstrated through cell imaging.",

keywords = "Betaine, Fluorescent, Graphene oxide, pH sensor",

author = "Lihua Lu and Chenfu Liu and Guodong Li and Liu, {Li Juan} and Leung, {Chung Hang} and Ma, {Dik Lung}",

note = "Funding Information: This work was funded by the Project of Shandong Province Higher Educational Science and Technology Program (J17KA109) and the Research Foundation for Distinguished Scholars of Qingdao Agricultural University (No. 663-1116010), Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522 and HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (077/2016/A2 and 007/2014/AMJ), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), and the National Natural Science Foundation of China (21628502). ",

year = "2018",

month = mar,

doi = "10.1016/j.snb.2017.11.047",

language = "English",

volume = "257",

pages = "860--865",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

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T1 - Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

AU - Lu, Lihua

AU - Liu, Chenfu

AU - Li, Guodong

AU - Liu, Li Juan

AU - Leung, Chung Hang

AU - Ma, Dik Lung

N1 - Funding Information: This work was funded by the Project of Shandong Province Higher Educational Science and Technology Program (J17KA109) and the Research Foundation for Distinguished Scholars of Qingdao Agricultural University (No. 663-1116010), Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522 and HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (077/2016/A2 and 007/2014/AMJ), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), and the National Natural Science Foundation of China (21628502).

PY - 2018/3

Y1 - 2018/3

N2 - A novel graphene oxide (GO)-based pH sensor was designed and prepared through covalently attaching a zwitterionic betaine molecule onto a GO surface. This betaine-modified GO (BMGO) exhibited high water solubility and low toxicity. In aqueous media, BMGO displayed increased fluorescence in acidic conditions and decreased fluorescence in basic conditions. BMGO possesses a pH sensing range from 4 to 12 with excellent reversibility, quick response and high stability. With its high sensitivity and robustness, BMGO can be used to monitor the pH of intracellular contents, as demonstrated through cell imaging.

AB - A novel graphene oxide (GO)-based pH sensor was designed and prepared through covalently attaching a zwitterionic betaine molecule onto a GO surface. This betaine-modified GO (BMGO) exhibited high water solubility and low toxicity. In aqueous media, BMGO displayed increased fluorescence in acidic conditions and decreased fluorescence in basic conditions. BMGO possesses a pH sensing range from 4 to 12 with excellent reversibility, quick response and high stability. With its high sensitivity and robustness, BMGO can be used to monitor the pH of intracellular contents, as demonstrated through cell imaging.

KW - Betaine

KW - Fluorescent

KW - Graphene oxide

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JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

ER -

Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

Abstract

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