Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

Lihua Lu*, Chenfu LIU, Guodong Li, Li Juan Liu, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A novel graphene oxide (GO)-based pH sensor was designed and prepared through covalently attaching a zwitterionic betaine molecule onto a GO surface. This betaine-modified GO (BMGO) exhibited high water solubility and low toxicity. In aqueous media, BMGO displayed increased fluorescence in acidic conditions and decreased fluorescence in basic conditions. BMGO possesses a pH sensing range from 4 to 12 with excellent reversibility, quick response and high stability. With its high sensitivity and robustness, BMGO can be used to monitor the pH of intracellular contents, as demonstrated through cell imaging.

Original languageEnglish
Pages (from-to)860-865
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume257
DOIs
Publication statusPublished - Mar 2018

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

User-Defined Keywords

  • Betaine
  • Fluorescent
  • Graphene oxide
  • pH sensor

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