Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor

Xiang Sheng Song; Xiao Zhong Zhou; Ge Zhang; Qi Rong Dong; Ling Qin

doi:10.1016/j.mehy.2010.07.012

Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor

Xiang Sheng Song
, Xiao Zhong Zhou^*
, Ge Zhang
, Qi Rong Dong
, Ling Qin

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

Compared with high and medium dose irradiation, low-dose irradiation (LDI) revealed different yet healing promotion effects, such as hormesis and adaptive response. A recent milestone work by Zhou demonstrated that LDI at 1. Gy promoted callus formation and mineralization in a rat model, yet without being able to address the underlying mechanism. It is well known that vascular endothelial growth factor (VEGF) is a key cytokine that regulates angiogenesis, especially important found in the process of fracture healing to interplay with other molecules. Furthermore, recent studies revealed that tissue repair might be enhanced by LDI through up-regulation of the level of VEGF. In view of this general phenomenon, we propose the following hypothesis that low-dose X-ray irradiation at ≤1. Gy promotes fracture healing through up-regulation of VEGF.

Original language	English
Pages (from-to)	522-524
Number of pages	3
Journal	Medical Hypotheses
Volume	75
Issue number	6
DOIs	https://doi.org/10.1016/j.mehy.2010.07.012
Publication status	Published - Dec 2010

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10.1016/j.mehy.2010.07.012

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title = "Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor",

abstract = "Compared with high and medium dose irradiation, low-dose irradiation (LDI) revealed different yet healing promotion effects, such as hormesis and adaptive response. A recent milestone work by Zhou demonstrated that LDI at 1. Gy promoted callus formation and mineralization in a rat model, yet without being able to address the underlying mechanism. It is well known that vascular endothelial growth factor (VEGF) is a key cytokine that regulates angiogenesis, especially important found in the process of fracture healing to interplay with other molecules. Furthermore, recent studies revealed that tissue repair might be enhanced by LDI through up-regulation of the level of VEGF. In view of this general phenomenon, we propose the following hypothesis that low-dose X-ray irradiation at ≤1. Gy promotes fracture healing through up-regulation of VEGF.",

author = "Song, \{Xiang Sheng\} and Zhou, \{Xiao Zhong\} and Ge Zhang and Dong, \{Qi Rong\} and Ling Qin",

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T1 - Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor

AU - Song, Xiang Sheng

AU - Zhou, Xiao Zhong

AU - Zhang, Ge

AU - Dong, Qi Rong

AU - Qin, Ling

PY - 2010/12

Y1 - 2010/12

N2 - Compared with high and medium dose irradiation, low-dose irradiation (LDI) revealed different yet healing promotion effects, such as hormesis and adaptive response. A recent milestone work by Zhou demonstrated that LDI at 1. Gy promoted callus formation and mineralization in a rat model, yet without being able to address the underlying mechanism. It is well known that vascular endothelial growth factor (VEGF) is a key cytokine that regulates angiogenesis, especially important found in the process of fracture healing to interplay with other molecules. Furthermore, recent studies revealed that tissue repair might be enhanced by LDI through up-regulation of the level of VEGF. In view of this general phenomenon, we propose the following hypothesis that low-dose X-ray irradiation at ≤1. Gy promotes fracture healing through up-regulation of VEGF.

AB - Compared with high and medium dose irradiation, low-dose irradiation (LDI) revealed different yet healing promotion effects, such as hormesis and adaptive response. A recent milestone work by Zhou demonstrated that LDI at 1. Gy promoted callus formation and mineralization in a rat model, yet without being able to address the underlying mechanism. It is well known that vascular endothelial growth factor (VEGF) is a key cytokine that regulates angiogenesis, especially important found in the process of fracture healing to interplay with other molecules. Furthermore, recent studies revealed that tissue repair might be enhanced by LDI through up-regulation of the level of VEGF. In view of this general phenomenon, we propose the following hypothesis that low-dose X-ray irradiation at ≤1. Gy promotes fracture healing through up-regulation of VEGF.

UR - https://www.scopus.com/pages/publications/77958461192

U2 - 10.1016/j.mehy.2010.07.012

DO - 10.1016/j.mehy.2010.07.012

M3 - Journal article

C2 - 20673704

AN - SCOPUS:77958461192

SN - 0306-9877

VL - 75

SP - 522

EP - 524

JO - Medical Hypotheses

JF - Medical Hypotheses

IS - 6

ER -

Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor

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