Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells

Wanhe Wang, Lihua Lu, Ke Jia Wu, Jinshui Liu, Chung Hang Leung, Chun Yuen Wong*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Periodate (IO4) is a widely used reagent in organic synthesis and for biomolecular modification. However, highly sensitive fluorescence detection methods for IO4 are lacking. In this work, we designed and synthesized iridium(III) complexes for the detection of IO4 by the incorporation of a methylthio group to serve as a luminescence trigger. The results showed that complex 1 could detect IO4 in a sensitive and selective manner with a detection limit of 0.077 μM, rendering it more sensitive than reported fluorescence methods. Meanwhile, its inherently long emission lifetime enables its luminescence response to IO4 to be detected even in the presence of organic dyes by the use of time-resolved emission spectroscopy (TRES). This probe was further demonstrated to detect IO4 in living cells. To our knowledge, complex 1 is first long-lived iridium(III)-based probe for the sensitive detection of IO4, and is also one of few existing imaging probes for IO4.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume288
DOIs
Publication statusPublished - 1 Jun 2019

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

User-Defined Keywords

  • Cell imaging
  • Iridium(III) complex
  • Long emission lifetime
  • Luminescence probe
  • Periodate
  • Time-resolved emission spectroscopy

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