Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex

J. M. Mateos; J. Azkue; R. Sarría; R. Kuhn; P. Grandes; T. Knöpfel

doi:10.1007/s004180050211

Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex

J. M. Mateos
, J. Azkue
, R. Sarría
, R. Kuhn
, P. Grandes^*
, T. Knöpfel

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Journal article › peer-review

37 Citations (Scopus)

Abstract

The subcellular localization of the mGlu4a metabotropic glutamate receptor was investigated in rat cerebellum. At the light microscopical level, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed gold particles at the presynaptic sites of synapses made by parallel fiber terminals with dendritic spines of Purkinje cells. These observations support electrophysiological evidence indicating an autoreceptor function of mGlu4 receptors at these synapses.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Histochemistry and Cell Biology
Volume	109
Issue number	2
DOIs	https://doi.org/10.1007/s004180050211
Publication status	Published - Jan 1998

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User-Defined Keywords

Gold
Glutamate
Subcellular Localization
Purkinje Cell
Gold Particle

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10.1007/s004180050211

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title = "Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex",

abstract = "The subcellular localization of the mGlu4a metabotropic glutamate receptor was investigated in rat cerebellum. At the light microscopical level, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed gold particles at the presynaptic sites of synapses made by parallel fiber terminals with dendritic spines of Purkinje cells. These observations support electrophysiological evidence indicating an autoreceptor function of mGlu4 receptors at these synapses.",

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author = "Mateos, \{J. M.\} and J. Azkue and R. Sarr{\'i}a and R. Kuhn and P. Grandes and T. Kn{\"o}pfel",

note = "We thank D. R{\"u}egg for excellent help in the generation and purification of the antiserum. Part of this work has been supported by Gobierno Vasco grant PI94/77 and DGICYT grant PB95-0347 (J.M.M., J.A., R.S., P.G.). J.M.M. and J.A. were in receipt of a fellowship from Gobierno Vasco (grants BFI 95.154 and BFI 95.017, respectively). Publisher copyright: {\textcopyright} Springer-Verlag 1998",

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AU - Mateos, J. M.

AU - Azkue, J.

AU - Sarría, R.

AU - Kuhn, R.

AU - Grandes, P.

AU - Knöpfel, T.

N1 - We thank D. Rüegg for excellent help in the generation and purification of the antiserum. Part of this work has been supported by Gobierno Vasco grant PI94/77 and DGICYT grant PB95-0347 (J.M.M., J.A., R.S., P.G.). J.M.M. and J.A. were in receipt of a fellowship from Gobierno Vasco (grants BFI 95.154 and BFI 95.017, respectively). Publisher copyright: © Springer-Verlag 1998

PY - 1998/1

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N2 - The subcellular localization of the mGlu4a metabotropic glutamate receptor was investigated in rat cerebellum. At the light microscopical level, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed gold particles at the presynaptic sites of synapses made by parallel fiber terminals with dendritic spines of Purkinje cells. These observations support electrophysiological evidence indicating an autoreceptor function of mGlu4 receptors at these synapses.

AB - The subcellular localization of the mGlu4a metabotropic glutamate receptor was investigated in rat cerebellum. At the light microscopical level, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed gold particles at the presynaptic sites of synapses made by parallel fiber terminals with dendritic spines of Purkinje cells. These observations support electrophysiological evidence indicating an autoreceptor function of mGlu4 receptors at these synapses.

KW - Gold

KW - Glutamate

KW - Subcellular Localization

KW - Purkinje Cell

KW - Gold Particle

UR - https://www.scopus.com/pages/publications/0031884643

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AN - SCOPUS:0031884643

SN - 0948-6143

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SP - 135

EP - 139

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

IS - 2

ER -

Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex

Abstract

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