Localization of glutamate receptors in dorsal horn of rat spinal cord

Kin Lam YUNG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)

Abstract

Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A- C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR 1/2 a was detected in laminae I-III of the dorsal horn, whilst mGluR2/3 immunoreactivity was detected primarily in lamina III. Immunoreactivity for NMDAR1, GluR1, GluR2, GluR2/3, GluR4 and GluR5/6/7 was strongly localized in neuronal elements of laminae I-III. Immunoreactivity for NMDAR2B was localized in laminae I-III. No mGluR5, NMDAR2A and NMDAR2C immunoreactivity was detected. In addition, immunoreactivity for receptors was found to co-localize with immunoreactivity for glutamate in the dorsal horn. The present results indicate that glutamate receptors are differentially localized in neuronal elements of dorsal horn where receptor- neurotransmitter interaction takes place.

Original languageEnglish
Pages (from-to)1639-1644
Number of pages6
JournalNeuroReport
Volume9
Issue number7
DOIs
Publication statusPublished - 11 May 1998

Scopus Subject Areas

  • Neuroscience(all)

User-Defined Keywords

  • AMPA receptors
  • Immunofluorescence
  • Light microscopy
  • NMDA receptors

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