Abstract
Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A- C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR 1/2 a was detected in laminae I-III of the dorsal horn, whilst mGluR2/3 immunoreactivity was detected primarily in lamina III. Immunoreactivity for NMDAR1, GluR1, GluR2, GluR2/3, GluR4 and GluR5/6/7 was strongly localized in neuronal elements of laminae I-III. Immunoreactivity for NMDAR2B was localized in laminae I-III. No mGluR5, NMDAR2A and NMDAR2C immunoreactivity was detected. In addition, immunoreactivity for receptors was found to co-localize with immunoreactivity for glutamate in the dorsal horn. The present results indicate that glutamate receptors are differentially localized in neuronal elements of dorsal horn where receptor- neurotransmitter interaction takes place.
| Original language | English |
|---|---|
| Pages (from-to) | 1639-1644 |
| Number of pages | 6 |
| Journal | NeuroReport |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 11 May 1998 |
Scopus Subject Areas
- General Neuroscience
User-Defined Keywords
- AMPA receptors
- Immunofluorescence
- Light microscopy
- NMDA receptors