Localization of GABA transaminase immunoreactivity in the rat substantia nigra pars reticulata

Kin Lam YUNG*, Y. C. Tse, Z. G. Gao, S. Y. Choi, F. S.L. Kwok

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

8 Citations (Scopus)


Precise cellular localization of gamma-aminobutyric acid transaminase (GABA(T)), a degrading enzyme for the neurotransmitter GABA, was determined in the rat substantia nigra (SN) by immunocytochemical experiments using a recently developed monoclonal antibody. In order to characterize the GABA(T)- immunoreactive neurons, double immunocytochemistry was also performed using tyrosine hydroxylase (TH) as a neurochemical marker for dopaminergic neurons in the substantia nigra pars compacta (SNc). Immunoreactivity for GABA(T) was primarily localized in perikarya of the SN. There were only a few GABA(T)- immunoreactive neurons found to display TH immunoreactivity. Most of the GABA(T)-immunoreactive neurons were then identified as reticulata neurons. These results indicate that reticulata neurons are the major nigral neurons that express GABA(T) immunoreactivity and there may be functional compartmentalization of the GABA metabolism in the rat substantia nigra pars reticulata (SNr).

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 28 Aug 1998

Scopus Subject Areas

  • Neuroscience(all)

User-Defined Keywords

  • Gamma-aminobutyric acid transaminase
  • Rat substantia nigra pars reticulata
  • Tyrosine hydroxylase


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