Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

Z. Q. Lei*, L. Li, G. J. Li, C. W. Leung, Jue SHI, C. M. Wong, K. C. Lo, W. K. Chan, C. S.K. Mak, S. B. Chan, N. M.M. Chan, C. H. Leung, P. T. Lai, P. W.T. Pong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.

Original languageEnglish
Article number07E505
JournalJournal of Applied Physics
Volume111
Issue number7
DOIs
Publication statusPublished - 1 Apr 2012

Scopus Subject Areas

  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors'. Together they form a unique fingerprint.

Cite this