Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

David G. Smith; Brian K. Mc Mahon; Robert Pal; David Parker

doi:10.1039/c2cc34267g

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

David G. Smith, Brian K. Mc Mahon, Robert Pal, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

125 Citations (Scopus)

Abstract

Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

Original language	English
Pages (from-to)	8520-8522
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	68
Early online date	11 Jul 2012
DOIs	https://doi.org/10.1039/c2cc34267g
Publication status	Published - 4 Sept 2012

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10.1039/c2cc34267g

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title = "Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes",

abstract = "Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.",

author = "Smith, {David G.} and {Mc Mahon}, {Brian K.} and Robert Pal and David Parker",

note = "We thank the ERC (FCC 266804) and EPSRC for support. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2012",

year = "2012",

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day = "4",

doi = "10.1039/c2cc34267g",

language = "English",

volume = "48",

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journal = "Chemical Communications",

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T1 - Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

AU - Smith, David G.

AU - Mc Mahon, Brian K.

AU - Pal, Robert

AU - Parker, David

N1 - We thank the ERC (FCC 266804) and EPSRC for support. Publisher Copyright: © The Royal Society of Chemistry 2012

PY - 2012/9/4

Y1 - 2012/9/4

N2 - Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

AB - Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

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UR - https://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc34267g

U2 - 10.1039/c2cc34267g

DO - 10.1039/c2cc34267g

M3 - Journal article

C2 - 22820610

AN - SCOPUS:84864482344

SN - 1359-7345

VL - 48

SP - 8520

EP - 8522

JO - Chemical Communications

JF - Chemical Communications

IS - 68

ER -

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

Abstract

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