TY - JOUR
T1 - Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study
AU - Liang, Yanshan
AU - Tang, Zhi
AU - Jiang, Yousheng
AU - Ai, Chunyan
AU - Peng, Jinling
AU - Liu, Yuan
AU - Chen, Jinru
AU - Xin, Xiong
AU - Lei, Bo
AU - Zhang, Jianqing
AU - Cai, Zongwei
N1 - This work was financially supported by the National Key Research and Development Program of China (No. 2017YFC1600500 and 2018YFA0901104), Shenzhen Science Technology and Innovation Commission (No. JCYJ20170413102320786), and Sanming Project of Medicine in Shenzhen (SZSM201811070).
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Dioxins, environmentally stable and ubiquitous, have been found to induce metabolic changes especially in lipids and be related to multiple diseases. However, limited study is available on lipid alternations related to human exposure to dioxins. This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin exposure caused accumulations of triglyceride (TG), ceramide (Cer) and sphingoid (So), remodeling of glycerophospholipid (GP), imbalanced FFA metabolism, as well as upregulation of platelet-activating factor (PAF). These findings implied the associations between dioxin exposure and potential adverse health risks including inflammation, apoptosis, cardiovascular diseases (CVDs), and liver diseases. This study is the first to explain the associations between dioxin exposure and health effects at the level of lipid metabolism.
AB - Dioxins, environmentally stable and ubiquitous, have been found to induce metabolic changes especially in lipids and be related to multiple diseases. However, limited study is available on lipid alternations related to human exposure to dioxins. This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin exposure caused accumulations of triglyceride (TG), ceramide (Cer) and sphingoid (So), remodeling of glycerophospholipid (GP), imbalanced FFA metabolism, as well as upregulation of platelet-activating factor (PAF). These findings implied the associations between dioxin exposure and potential adverse health risks including inflammation, apoptosis, cardiovascular diseases (CVDs), and liver diseases. This study is the first to explain the associations between dioxin exposure and health effects at the level of lipid metabolism.
KW - Dioxins
KW - Lipid profiles
KW - Male workers
KW - Serum
UR - http://www.scopus.com/inward/record.url?scp=85108104421&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2021.106665
DO - 10.1016/j.envint.2021.106665
M3 - Journal article
C2 - 34098336
AN - SCOPUS:85108104421
SN - 0160-4120
VL - 155
JO - Environment International
JF - Environment International
M1 - 106665
ER -