Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

Thomas J. Clough, Lijun Jiang, Ka-Leung WONG, Nicholas J. Long*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

66 Citations (Scopus)

Abstract

Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.

Original languageEnglish
Article number1420
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Dec 2019

Scopus Subject Areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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