Lifespan associations of resting-state brain functional networks with ADHD symptoms

Rong Wang*, Yongchen Fan, Ying Wu, Yu Feng Zang, Changsong Zhou*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

5 Citations (Scopus)


Attention-deficit/hyperactivity disorder (ADHD) is increasingly being diagnosed in both children and adults, but the neural mechanisms that underlie its distinct symptoms and whether children and adults share the same mechanism remain poorly understood. Here, we used a nested-spectral partition approach to study resting-state brain networks of ADHD patients (n = 97) and healthy controls (HCs, n = 97) across the lifespan (7–50 years). Compared to the linear lifespan associations of brain segregation and integration with age in HCs, ADHD patients have a quadratic association in the whole-brain and in most functional systems, whereas the limbic system dominantly affected by ADHD has a linear association. Furthermore, the limbic system better predicts hyperactivity, and the salient attention system better predicts inattention. These predictions are shared in children and adults with ADHD. Our findings reveal a lifespan association of brain networks with ADHD and provide potential shared neural bases of distinct ADHD symptoms in children and adults.

Original languageEnglish
Article number104673
Number of pages18
Issue number7
Publication statusPublished - 15 Jul 2022

Scopus Subject Areas

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