Leveraging functional annotations in genetic risk prediction for human complex diseases

Yiming Hu, Qiongshi Lu, Ryan Powles, Xinwei Yao, Can YANG, Fang Fang, Xinran Xu, Hongyu Zhao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Genetic risk prediction is an important goal in human genetics research and precision medicine. Accurate prediction models will have great impacts on both disease prevention and early treatment strategies. Despite the identification of thousands of disease-associated genetic variants through genome wide association studies (GWAS), genetic risk prediction accuracy remains moderate for most diseases, which is largely due to the challenges in both identifying all the functionally relevant variants and accurately estimating their effect sizes in the presence of linkage disequilibrium. In this paper, we introduce AnnoPred, a principled framework that leverages diverse types of genomic and epigenomic functional annotations in genetic risk prediction for complex diseases. AnnoPred is trained using GWAS summary statistics in a Bayesian framework in which we explicitly model various functional annotations and allow for linkage disequilibrium estimated from reference genotype data. Compared with state-of-the-art risk prediction methods, AnnoPred achieves consistently improved prediction accuracy in both extensive simulations and real data.

Original languageEnglish
Article numbere1005589
JournalPLoS Computational Biology
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2017

Scopus Subject Areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Modelling and Simulation
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

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