Learning Tensor-Based Features for Whole-Brain fMRI Classification

Xiaonan Song, Lingnan Meng, Qiquan Shi, Haiping LU*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

9 Citations (Scopus)

Abstract

This paper presents a novel tensor-based feature learning approach for whole-brain fMRI classification. Whole-brain fMRI data have high exploratory power, but they are challenging to deal with due to large numbers of voxels. A critical step for fMRI classification is dimensionality reduction, via feature selection or feature extraction. Most current approaches perform voxel selection based on feature selection methods. In contrast, feature extraction methods, such as principal component analysis (PCA), have limited usage on whole brain due to the small sample size problem and limited interpretability. To address these issues, we propose to directly extract features from natural tensor (rather than vector) representations of whole-brain fMRI using multilinear PCA (MPCA), and map MPCA bases to voxels for interpretability. Specifically, we extract low-dimensional tensors by MPCA, and then select a number of MPCA features according to the captured variance or mutual information as the input to SVM. To provide interpretability, we construct a mapping from the selected MPCA bases to raw voxels for localizing discriminating regions. Quantitative evaluations on challenging multiclass tasks demonstrate the superior performance of our proposed methods against the state-of-the-art, while qualitative analysis on localized discriminating regions shows the spatial coherence and interpretability of our mapping

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2015
Subtitle of host publication18th International Conference, Munich, Germany, October 5-9, 2015, Proceedings, Part I
EditorsNassir Navab, Joachim Hornegger, William M. Wells, Alejandro Frangi
PublisherSpringer, Cham
Pages613-620
Number of pages8
Edition1st
ISBN (Electronic)9783319245539
ISBN (Print)9783319245522
DOIs
Publication statusPublished - 18 Nov 2015

Publication series

NameLecture Notes in Computer Science
Volume9349
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Scopus Subject Areas

  • Theoretical Computer Science
  • Computer Science(all)

User-Defined Keywords

  • Autism Spectrum Disorder
  • Feature Selection
  • Feature Selection Method
  • fMRI Data
  • Kernel Principal Component Analysis

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