Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

Chenchen Song; Tinya Chang; Tobias Buchborn; Thomas Knöpfel

doi:10.1101/2025.03.10.642385

Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

Chenchen Song^*
, Tinya Chang
, Tobias Buchborn
, Thomas Knöpfel

^*Corresponding author for this work

Department of Physics

Research output: Working paper › Preprint

Abstract

The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by pharmacological inhibition of DNA methyltransferase I, indicating an epigenetic mechanism underlying the long-lasting effect of psilocybin.

Original language	English
Publisher	Cold Spring Harbor Laboratory
DOIs	https://doi.org/10.1101/2025.03.10.642385
Publication status	Published - 11 Mar 2025

Publication series

Name	bioRxiv
ISSN (Print)	2692-8205

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1101/2025.03.10.642385

Cite this

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abstract = "The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by pharmacological inhibition of DNA methyltransferase I, indicating an epigenetic mechanism underlying the long-lasting effect of psilocybin.",

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Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

Abstract

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UN SDGs

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