@techreport{99c7c8a1ca744a38b8553f170f873e37,
title = "Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition",
abstract = "The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by pharmacological inhibition of DNA methyltransferase I, indicating an epigenetic mechanism underlying the long-lasting effect of psilocybin.",
author = "Chenchen Song and Tinya Chang and Tobias Buchborn and Thomas Kn{\"o}pfel",
year = "2025",
month = mar,
day = "11",
doi = "10.1101/2025.03.10.642385",
language = "English",
series = "bioRxiv",
publisher = "Cold Spring Harbor Laboratory Press",
address = "United States",
type = "WorkingPaper",
institution = "Cold Spring Harbor Laboratory Press",
}
